{
  "abstract": "Manganese dioxide is a material that is more and more used in its particular form, for many industrial applications such as chemical catalysis or for batteries. Thus, workers can be exposed to this particulate chemical. It is known that overexposure to manganese leads to a brain disease called manganism. However, manganese is also known to impact the pulmonary function, which is important as pulmonary exposure is of prime importance for workers. We thus investigated the effects of manganese dioxide on macrophages, i.e. the scavenger cells that take particulates in charge in our bodies. To this purpose, we used a combination of proteomic and targeted approaches, in order to obtain a wide view of the cellular responses to manganese dioxide. We also used a repeated exposure mode, in order to better mimic occupational exposure. Our results point out the fact that manganese oxide nanoparticles are toxic for macrophages and induce mitochondrial dysfunction, oxidative stress and a pro-inflammatory response.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Marianne Vitipon"
    },
    {
      "name": "Esther Akingbagbohun"
    },
    {
      "name": "Véronique Collin-Faure"
    },
    {
      "name": "Fabienne Devime"
    },
    {
      "name": "Hélène Diemer"
    },
    {
      "name": "Daphna Fenel"
    },
    {
      "name": "Christine Carapito"
    },
    {
      "name": "Stéphane Ravanel"
    },
    {
      "name": "Thierry Rabilloud"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5eerznxrpwbb0.bib",
  "cited_by": 0,
  "doi": "10.1016/j.hazadv.2026.101337",
  "fulltext_url": null,
  "id": "5eerznxrpwbb0",
  "issns": [
    "2772-4166"
  ],
  "landing_url": "https://hal.science/hal-05751761v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
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    ],
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      "openalex",
      "2307|Heavy Metal Exposure and Toxicity"
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  "openalex": "W4414281141",
  "pdf_url": "https://hal.science/hal-05751761/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-16",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/5eerznxrpwbb0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "hal-05751761",
      "source": "hal",
      "url": "https://hal.science/hal-05751761v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.ee",
      "subfield": "ecology"
    },
    {
      "field": "biology",
      "origin": "hal:1.sdv.imm",
      "subfield": "immunology"
    },
    {
      "field": "medicine",
      "origin": "hal:2.sdv.ee.sant",
      "subfield": "epidemiology-public-health"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.tox",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Effects of manganese dioxide on macrophages under different exposure schemes",
  "title_text": "Effects of manganese dioxide on macrophages under different exposure schemes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:35Z",
  "url": "https://research.draconitic.com/paper/5eerznxrpwbb0",
  "venue": "Journal of Hazardous Materials Advances",
  "versions": []
}