{
  "abstract": "Objective: Diagnosing cerebrospinal fluid (CSF) infection in neurosurgical patients with ventricular devices is challenging due to nonspecific clinical features, prior antibiotic exposure, and delayed microbiological confirmation. Rapid bedside biomarkers that can reliably support early diagnosis are therefore needed. This study explored the preliminary diagnostic performance and feasibility of the combined lactate–glucose ratio (CLGR), measured using a point-of-care blood gas analyzer, for early detection of CSF infection in a neurosurgical intensive care unit (ICU) population.\n\nMethods: In this prospective, single-center pilot study reported per Standards for Reporting of Diagnostic Accuracy Studies (STARD) 2015, 62 neurosurgical ICU patients were screened; 48 enrolled, 47 analyzed. CSF lactate/glucose were measured using point-of-care arterial blood gas analyzer (blinded to culture); CLGR calculated. Culture positivity was the reference standard.\n\nResults: Eighteen (37.5%) had culture-positive infection. Median CLGR was higher in infected cases (14.48 vs. 6.35, p<0.0001). At CLGR ≥10, sensitivity was 83.3%, specificity 82.8% (area under the curve, 0.868). Results were available in 4 minutes (interquartile range, 3–5) with a 0% failure rate.\n\nConclusion: The CLGR demonstrates strong potential as a rapid, feasible, and reliable bedside biomarker for diagnosing CSF infection in neurosurgical patients. Point-of-care CLGR measurement may serve as a rapid, adjunctive bedside tool for initial risk stratification, complementing conventional CSF analysis while awaiting definitive microbiological results.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesia, Paras Health Srinagar, Srinagar, India .",
    "Department of Neurosurgery, Government Medical College (GMC), Srinagar, India .",
    "Department of Microbiology, Government Medical College (GMC), Anantnag, India .",
    "Department of Medicine, Government Medical College (GMC), Srinagar, India .",
    "Department of Anesthesia, Government Medical College (GMC), Srinagar, India ."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Adnan Qadri",
      "orcid": "0009-0004-3517-389X"
    },
    {
      "affs": [
        1
      ],
      "name": "Ishtiyaq Hussain",
      "orcid": "0009-0001-9579-0935"
    },
    {
      "affs": [
        2
      ],
      "name": "Mehreen Syed Gurcoo",
      "orcid": "0009-0006-4587-503X"
    },
    {
      "affs": [
        3
      ],
      "name": "Duha Wani",
      "orcid": "0009-0000-8875-9190"
    },
    {
      "affs": [
        4
      ],
      "name": "Rafiya Gull",
      "orcid": "0009-0001-9956-1240"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5f2dtz55h2dv1.bib",
  "cited_by": 0,
  "doi": "10.13004/kjnt.2026.22.e38",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13745172/",
  "id": "5f2dtz55h2dv1",
  "issns": [
    "2234-8999",
    "2288-2243"
  ],
  "landing_url": "https://doi.org/10.13004/kjnt.2026.22.e38",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Article"
    ],
    [
      "openalex",
      "2404|Bacterial Infections and Vaccines"
    ]
  ],
  "openalex": "W7223704390",
  "pdf_url": "https://europepmc.org/articles/PMC13745172?pdf=render",
  "pmcid": "PMC13745172",
  "pmid": "43005021",
  "published": "2026-09-14",
  "publisher": "Korean Neurotraumatology Society",
  "ris": "https://research.draconitic.com/paper/5f2dtz55h2dv1.ris",
  "sources": [
    {
      "first_seen": "2026-11-11T12:22:46Z",
      "native_id": "PMC13745172",
      "source": "pmc",
      "url": "https://doi.org/10.13004/kjnt.2026.22.e38"
    },
    {
      "first_seen": "2026-11-12T15:22:43Z",
      "native_id": "MED:43005021",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/43005021"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2404|Bacterial Infections and Vaccines",
      "subfield": "microbiology"
    }
  ],
  "title": "Bedside Feasibility and Preliminary Diagnostic Performance of the Point-of-Care Combined Lactate–Glucose Ratio for Detecting Cerebrospinal Fluid Infection in Neurosurgical Patients: A Pilot Study",
  "title_text": "Bedside Feasibility and Preliminary Diagnostic Performance of the Point-of-Care Combined Lactate–Glucose Ratio for Detecting Cerebrospinal Fluid Infection in Neurosurgical Patients: A Pilot Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:20:39Z",
  "url": "https://research.draconitic.com/paper/5f2dtz55h2dv1",
  "venue": "Korean Journal of Neurotrauma",
  "versions": []
}