{
  "abstract": "Duck viral hepatitis (DVH), caused by duck hepatitis A virus genotype 3 (DHAV-3), is a highly lethal infectious disease in ducklings, yet the key host determinants underlying differential resistance remain unclear. Using previously established DHAV-3-resistant (Z7R) and -susceptible (Z7S) Pekin duck models, we investigated the molecular mechanisms driving host resistance to DHAV-3. Resistant ducks exhibited significantly lower viral load and reduced viral replication compared to susceptible ducks, while heightened interferon-induced transmembrane protein 1 (IFITM1) expression levels in susceptible ducks were associated with severe hepatic tissue damage. Strikingly, functional analyses revealed that IFITM1-mediated resistance is not solely dependent on its expression level but involves regulation of host cell cycle progression at the G1 phase during viral infection. Mechanistically, we identified a novel interaction between IFITM1, the host antiviral sensor IFIT5, and the viral capsid protein VP1, which together form a regulatory axis that modulates antiviral defense and cell-cycle control. Among DHAV-3 structural proteins, VP1 was the only component showing differential expression between resistant and susceptible ducks. These findings identify IFITM1 as an essential host factor that mediates antiviral defense against DHAV-3 and provide mechanistic insights into the IFITM1-IFIT5-VP1 axis, linking innate immunity, cell-cycle regulation, and viral pathogenesis.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian district, Beijing, 100193, People's Republic of China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Suyun Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Meixi Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Huihui Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuisheng Hou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5f6pb1bsz6edm.bib",
  "cited_by": 0,
  "doi": "10.1016/j.psj.2026.107936",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735276/",
  "id": "5f6pb1bsz6edm",
  "issns": [
    "0032-5791",
    "1525-3171"
  ],
  "landing_url": "https://doi.org/10.1016/j.psj.2026.107936",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Full-Length Article"
    ],
    [
      "openalex",
      "2403|interferon and immune responses"
    ]
  ],
  "openalex": "W7221443011",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S0032579126015701/pdf",
  "pmcid": "PMC13735276",
  "pmid": "42945834",
  "published": "2026-10-11",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/5f6pb1bsz6edm.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:59Z",
      "native_id": "PMC13735276",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.psj.2026.107936"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|interferon and immune responses",
      "subfield": "immunology"
    }
  ],
  "title": "Divergent IFITM1 regulation is associated with resistance and susceptibility to duck hepatitis A virus genotype 3 in Pekin ducks",
  "title_text": "Divergent IFITM1 regulation is associated with resistance and susceptibility to duck hepatitis A virus genotype 3 in Pekin ducks",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:59Z",
  "url": "https://research.draconitic.com/paper/5f6pb1bsz6edm",
  "venue": "Poultry Science",
  "versions": []
}