{
  "abstract": "Background: We report a case to demonstrate that targeted eosinophil depletion with Benralizumab (anti-IL-5 receptor α therapy) can induce the complete functional and structural reversal of advanced EGPA-associated cardiomyopathy. Case Presentation: A 56-year-old woman with a decade-long history of EGPA presented with progressive nonischemic dilated cardiomyopathy and a nadir ejection fraction of 25–30%. Cardiac MRI demonstrated diffuse nonischemic late gadolinium enhancement consistent with eosinophil-mediated myocardial injury. Despite the optimization of guideline-directed medical therapy, complete recovery was not achieved until benralizumab was initiated. Following biologic therapy, the ejection fraction recovered to 50% and severe mitral regurgitation regressed to mild. The exercise capacity was preserved throughout, with a peak VO2 of 117% and 111% of predicted before and after biologic therapy, respectively. The patient remains in NYHA Class I at the one-year follow-up. Discussion: We describe a case with EGPA-associated non-ischemic cardiomyopathy treated with benralizumab achieving the complete recovery of ventricular function and achieving the complete independence of steroid therapy. Conclusions: This case emphasizes the importance of identifying the inflammatory etiology of cardiomyopathy, optimizing GDMT systematically, and considering targeted biologic therapy directed at the underlying disease.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Heart Failure and Transplant, Mayo Clinic Florida, Jacksonville, FL 32224, USA",
    "Department of Neurology, Mayo Clinic Florida, Jacksonville, FL 32224, USA",
    "Department of Infectious Diseases, Mayo Clinic Florida, Jacksonville, FL 32224, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Laxmi Raj Bangari",
      "orcid": "0009-0006-4404-0559"
    },
    {
      "affs": [
        1
      ],
      "name": "Yugant Khand"
    },
    {
      "affs": [
        2
      ],
      "name": "Vidit Yadav",
      "orcid": "0009-0009-3729-9724"
    },
    {
      "affs": [
        0
      ],
      "name": "Aarti Desai",
      "orcid": "0009-0006-2502-6153"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrea Muniz",
      "orcid": "0009-0009-8908-7512"
    },
    {
      "affs": [
        0
      ],
      "name": "Jose Ruiz"
    },
    {
      "affs": [
        0
      ],
      "name": "Jose Nativi-Nicolau",
      "orcid": "0000-0002-5481-2122"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan Leoni",
      "orcid": "0000-0001-7820-3842"
    },
    {
      "affs": [
        0
      ],
      "name": "Parag Patel"
    },
    {
      "affs": [
        0
      ],
      "name": "Rohan Goswami",
      "orcid": "0000-0002-0921-1416"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5fbd6bw18n56w.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15208057",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705968/?tool=EBI",
  "id": "5fbd6bw18n56w",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/8057",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2745|Eosinophilic Disorders and Syndromes"
    ]
  ],
  "openalex": "W7222975545",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705968/pdf/?tool=EBI",
  "pmcid": "PMC13705968",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/5fbd6bw18n56w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15208057",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/8057"
    },
    {
      "first_seen": "2026-10-30T12:21:25Z",
      "native_id": "PMC:PMC13705968",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705968"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Eosinophilic Disorders and Syndromes",
      "subfield": "general"
    }
  ],
  "title": "Heart Failure with Recovered Ejection Fraction: EGPA-Associated Cardiomyopathy Treated with Benralizumab",
  "title_text": "Heart Failure with Recovered Ejection Fraction: EGPA-Associated Cardiomyopathy Treated with Benralizumab",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:25Z",
  "url": "https://research.draconitic.com/paper/5fbd6bw18n56w",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}