{
  "abstract": "). Associations were examined using Spearman's ρ, and the discrimination of severe coronary artery calcification (CAC) (Agatston ≥400) was evaluated using a receiver operating characteristic (ROC) curve analysis. Results CAC was correlated with FGF-23 (ρ=0.379, p=0.002), but not with fetuin-A or OPG. FGF-23 was also associated with the aortic arch (ρ=0.284, p=0.019), abdominal aortic calcification (ρ=0.311, p=0.010), and left ventricular mass index (ρ=0.425, p<0.001). For severe CAC, OPG showed the highest, albeit modest, discrimination (area under the ROC curve 0.69, 95% confidence interval 0.56-0.82; Youden cutoff 9.47), but it was not independently associated after adjusting for age. All biomarkers showed a weak association with aortic valve calcification. Conclusion In patients without advanced CKD, FGF-23 is associated with systemic vascular calcification and left ventricular remodeling, whereas OPG provides only a modest unadjusted discrimination for severe CAC and does not add to age. These findings suggest a limited, context-dependent role for these biomarkers, and underscore the need for larger, externally validated studies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Keisuke Senda"
    },
    {
      "name": "Nami Teraoka"
    },
    {
      "name": "Kazuma Masuda"
    },
    {
      "name": "Minami Inoue"
    },
    {
      "name": "Keisuke Machida"
    },
    {
      "name": "Katsuyuki Aizawa"
    },
    {
      "name": "Takahiro Takeuchi"
    },
    {
      "name": "Satoshi Yasukochi"
    },
    {
      "name": "Koichiro Kuwahara"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5fs971yqm52ws.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.6389-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/14/65_6389-25/_article",
  "id": "5fs971yqm52ws",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/14/65_6389-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2727|Parathyroid Disorders and Treatments"
    ]
  ],
  "openalex": "W4417209194",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6389-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5fs971yqm52ws.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.6389-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/14/65_6389-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Parathyroid Disorders and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Fibroblast Growth Factor 23 and Osteoprotegerin in Vascular Calcification among Patients without Advanced Chronic Kidney Disease",
  "title_text": "Fibroblast Growth Factor 23 and Osteoprotegerin in Vascular Calcification among Patients without Advanced Chronic Kidney Disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/5fs971yqm52ws",
  "venue": "Internal Medicine",
  "versions": []
}