{
  "abstract": "AIM: Chronic limb-threatening ischemia (CLTI), the most advanced stage of lower-extremity artery disease, is associated with high mortality and major amputation rates, even after revascularization. Thus, identifying patients with CLTI at a particularly high risk of poor outcomes is crucial for shared decision making. Recently, the C-reactive protein-to-albumin ratio (CAR) has emerged as a novel composite biomarker that reflects both the inflammatory and nutritional status. Nonetheless, the prognostic significance of CAR in patients with CLTI undergoing endovascular therapy (EVT) remains unclear. METHODS: Of 159 patients who underwent EVT for the first time between April 2010 and December 2023, 79 were included in this study. The patients were categorized into two groups using a CAR value of 0.17: the high-CAR group (CAR ≥ 0.17) and the low-CAR group (CAR ＜0.17). The primary endpoint was 1-year amputation-free survival (AFS) after EVT. RESULTS: The median follow-up period was 23 months (95% confidence interval [CI], 11-34). During the follow-up period, 56 patients (71%) died and 11 (14%) underwent major amputation. AFS was significantly reduced in the high-CAR group (log-rank P＜0.01). The CAR (hazard ratio: 1.43 per one-unit increase, 95% CI: 1.20-1.70, P＜0.01) was an independent predictor of reduced AFS following EVT. CONCLUSIONS: elevated preprocedural CAR was independently associated with reduced AFS after EVT in patients with CLTI. The CAR may serve as a valuable tool for evaluating patients with CLTI before EVT.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Akinori Satake"
    },
    {
      "name": "Takahiro Tokuda"
    },
    {
      "name": "Hiroaki Sawada"
    },
    {
      "name": "Masahiro Shimoda"
    },
    {
      "name": "Hirofumi Ohashi"
    },
    {
      "name": "Akihiro Suzuki"
    },
    {
      "name": "Yusuke Nakano"
    },
    {
      "name": "Hiroshi Takahashi"
    },
    {
      "name": "Akio Kodama"
    },
    {
      "name": "Makoto Narita"
    },
    {
      "name": "Tetsuya Amano"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5ft8sne8jckfk.bib",
  "cited_by": 0,
  "doi": "10.5551/jat.66108",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/jat/33/11/33_66108/_article",
  "id": "5ft8sne8jckfk",
  "issns": [
    "1880-3873",
    "1340-3478"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/jat/33/11/33_66108/_article",
  "language": null,
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2746|Peripheral Artery Disease Management"
    ]
  ],
  "openalex": "W7165140705",
  "pdf_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66108/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5ft8sne8jckfk.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:20:49Z",
      "native_id": "10.5551/jat.66108",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/jat/33/11/33_66108/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Peripheral Artery Disease Management",
      "subfield": "surgery"
    }
  ],
  "title": "C-reactive Protein-to-Albumin Ratio for Evaluating Patients with Chronic Limb-Threatening Ischemia Following Endovascular Therapy",
  "title_text": "C-reactive Protein-to-Albumin Ratio for Evaluating Patients with Chronic Limb-Threatening Ischemia Following Endovascular Therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:21Z",
  "url": "https://research.draconitic.com/paper/5ft8sne8jckfk",
  "venue": "Journal of Atherosclerosis and Thrombosis",
  "versions": []
}