{
  "abstract": "ObjectiveOur objective was to define the natural history of hyper IgE syndrome. Well, there have been a number of large cross-sectional studies. It has been difficult to provide anticipatory care for the growing adult population.\n\nMethodsThe USIDNET registry was used to identify patients with hyper IgE syndrome. We evaluated all patients regardless of genetic etiology. Complications were extracted as text from the problem list or ICD codes, and each complication was date stamped, which allowed us to estimate the age at which the complication arose.\n\nResultsMany of the complications previously identified were seen in this cohort. The most feared complications were uncommon, however, developmental delay and psychosis affected nearly a fifth of the cohort which has not been previously reported.\n\nConclusionsAs the number of adults with hyper IgE syndrome increases our awareness of late onset complications is important. Aspergillus and pneumatoceles were less common than seen in some other cohorts. However, the significant rate of psychosis will represent a significant challenge for clinicians.",
  "abstract_shown": true,
  "affiliations": [
    "Children's Hospital of Philadelphia"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "A. Mao"
    },
    {
      "name": "R. Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "K. E. Sullivan"
    },
    {
      "name": "R. Fuleihan"
    },
    {
      "name": "C. Cunningham-Rundles"
    },
    {
      "name": "J. Puck"
    },
    {
      "name": "R. Marsh"
    },
    {
      "name": "R. Abraham"
    },
    {
      "name": "L. D. Notarangelo"
    },
    {
      "name": "V. Vichare"
    },
    {
      "name": "USIDNET Network members"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5fz4sjt9yetq5.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.11.26362846",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.11.26362846v1.full",
  "id": "5fz4sjt9yetq5",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.11.26362846v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "allergy and immunology"
    ],
    [
      "openalex",
      "2403|Immunodeficiency and Autoimmune Disorders"
    ]
  ],
  "openalex": "W7212445043",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.11.26362846v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5fz4sjt9yetq5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:28Z",
      "native_id": "10.64898/2026.09.11.26362846",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.11.26362846v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immunodeficiency and Autoimmune Disorders",
      "subfield": "immunology"
    }
  ],
  "title": "Trajectory of Hyper IgE complications",
  "title_text": "Trajectory of Hyper IgE complications",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:28Z",
  "url": "https://research.draconitic.com/paper/5fz4sjt9yetq5",
  "venue": "medRxiv",
  "versions": []
}