{
  "abstract": "Pediatric nephrotic syndrome (NS) significantly increases cardiovascular risk, primarily through activation of the renin-angiotensin-aldosterone system (RAAS) and chronic inflammation. This study aimed to evaluate the relationship between serum aldosterone and interleukin 6 (IL-6) levels with carotid intima-media thickness (CIMT) in children with steroid-sensitive (SSNS) and steroid-resistant NS (SRNS), before and after treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB). This prospective, single-arm pretest-posttest study included 32 children aged 2-18 years with idiopathic NS at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. Participants received lisinopril and valsartan for 12 weeks. Serum aldosterone was quantified by liquid chromatography-tandem mass spectrometry, IL-6 by electrochemiluminescence immunoassay, and CIMT by high-resolution B-mode Doppler ultrasound. Data were analyzed using SPSS version 26.0, including Shapiro-Wilk normality testing, correlation analyses, and multivariate linear regression, with statistical significance set at p<0.05. CIMT decreased significantly after treatment (0.13{+/-}0.04 cm to 0.06{+/-}0.01 cm; p<0.001). Serum aldosterone and IL-6 did not change significantly. Multivariate regression identified steroid resistance as associated with CIMT change, while aldosterone and IL-6 showed no significant independent effects.",
  "abstract_shown": true,
  "affiliations": [
    "Syiah Kuala University Faculty of Medicine: Universitas Syiah Kuala Fakultas Kedokteran"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "H. Dimiati"
    },
    {
      "name": "S. Haris"
    },
    {
      "name": "K. Hasballah"
    },
    {
      "name": "S. Pardede"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5g1y1n5dbn4qy.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.09.26365110",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.09.26365110v1.full",
  "id": "5g1y1n5dbn4qy",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.09.26365110v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "nephrology"
    ],
    [
      "openalex",
      "2727|Renal Diseases and Glomerulopathies"
    ]
  ],
  "openalex": "W7221659025",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.09.26365110v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5g1y1n5dbn4qy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:45Z",
      "native_id": "10.64898/2026.10.09.26365110",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.09.26365110v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:nephrology",
      "subfield": "general"
    }
  ],
  "title": "Vascular Remodelling in Idiopathic Nephrotic Syndrome with Administration of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers",
  "title_text": "Vascular Remodelling in Idiopathic Nephrotic Syndrome with Administration of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:45Z",
  "url": "https://research.draconitic.com/paper/5g1y1n5dbn4qy",
  "venue": "medRxiv",
  "versions": []
}