{
  "abstract": "Objective: Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC). Conventional biomarkers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) have diagnostic limitations, particularly for early-stage disease. This study investigated the expression profile of ORC1 in HBV-related liver disease and its association with HBV infection, disease progression, and prognosis.\n\nMethods: 178 participants were recruited: 124 HBV-positive cases (49 HBV-HCC, 33 HBV-cirrhosis, 42 chronic hepatitis B) and 54 HBV-negative controls (35 non-HBV-HCC, 19 hepatic hemangioma). Tissue ORC1 was detected by immunohistochemistry, and serum ORC1 was measured by ELISA in a subset of 17 HBV-HCC patients with available serum. Logistic regression identified factors associated with high ORC1 expression. ROC curves were used to evaluate the discrimination of tissue ORC1, AFP, and DCP for HBV-HCC, and the correlation between ORC1 and tumor diameter was analyzed. TCGA-LIHC data were used for external validation.\n\nResults: Tissue ORC1 was significantly upregulated in HBV-positive patients, and HBV infection was independently associated with high ORC1 expression (P<0. 001). ORC1 expression increased progressively from chronic hepatitis B to cirrhosis to HCC. In a subset of 17 HBV-HCC patients with available serum, tissue and serum ORC1 were moderately correlated (Spearman rs=0. 554, 95% CI 0. 085–0. 822, P = 0. 021). Tissue ORC1 showed moderate discrimination between HBV-HCC and HBV-LC (AUC = 0. 64) and between HBV-HCC and CHB (AUC = 0. 66). ORC1 expression was not significantly associated with tumor diameter ( P >0. 05). High ORC1 expression was associated with poorer overall survival in TCGA-LIHC (HR = 1. 7, P = 0. 0026).\n\nConclusion: ORC1 upregulation is independently associated with HBV infection and increases with disease progression in HBV-related liver disease. Although tissue ORC1 showed only moderate discrimination for HBV-HCC, high ORC1 expression was associated with poorer overall survival in TCGA-LIHC. These findings suggest that ORC1 is primarily a proliferation- and progression-related marker in HBV-related liver disease.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning",
    "Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning",
    "Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University), Ministry of Education, Nanning",
    "Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Nanning"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rong Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing-Mei Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Hang Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Tu-Mei Su"
    },
    {
      "affs": [
        0
      ],
      "name": "Qian-Bing Yin"
    },
    {
      "affs": [
        0
      ],
      "name": "Long Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong-Qian Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan-Fei Feng"
    },
    {
      "affs": [
        1
      ],
      "name": "Zi-Li Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Qian Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Ming-Hua Su"
    },
    {
      "affs": [
        0
      ],
      "name": "Bo-Bin Hu"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Jian-Ning Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5gt8hjvbryz7j.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1938736",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1938736/full",
  "id": "5gt8hjvbryz7j",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1938736/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "2721|Hepatocellular Carcinoma Treatment and Prognosis"
    ]
  ],
  "openalex": "W7223699010",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1938736/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5gt8hjvbryz7j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1938736",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1938736/full"
    },
    {
      "first_seen": "2026-10-30T13:47:20Z",
      "native_id": "5f8c2ed73e72466bb80abab77b6e8a9a",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fonc.2026.1938736"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC254-282",
      "subfield": "oncology"
    }
  ],
  "title": "ORC1 expression features and its prognostic significance in HBV-associated hepatocellular carcinoma",
  "title_text": "ORC1 expression features and its prognostic significance in HBV-associated hepatocellular carcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:20Z",
  "url": "https://research.draconitic.com/paper/5gt8hjvbryz7j",
  "venue": "Frontiers in Oncology",
  "versions": []
}