{
  "abstract": "Background: Clinically relevant postoperative pancreatic fistula (CR-POPF) and bile leakage (BL) are associated with high morbidity and mortality after pancreaticoduodenectomy (PD). Rescue pancreatectomy for CR-POPF after PD is also associated with major morbidity and mortality. Percutaneous transhepatic biliary drainage (PTBD) is a well-established treatment option for isolated bile leakage following PD. The efficacy of PTBD as a treatment option for clinically relevant biliopancreatic leakage after PD is still uncertain.\n\nMethods: Data from 543 patients scheduled for PD between 2014 and 2022 at Uppsala University Hospital, Sweden –– a tertiary referral centre –– were evaluated for clinically significant biliopancreatic, pancreatic or biliary leakage. Patients with unresolved leakage despite percutaneous intra-abdominal drainage were treated with PTBD. This study evaluates the technical success and clinical outcomes of this treatment.\n\nResults: PD was performed on 483 patients, of whom 83 (17%) had clinically relevant biliary, pancreatic or combined leakage. Thirty-nine (46%) of those with leakage received a PTBD, which was technically successful at the first procedure in 38 (97%) patients. Clinical success –– defined as discharge with closed PTBD, a resolved leak without the need for rescue pancreatectomy or in-hospital mortality –– was achieved in 32 (84%) patients. Two patients required an urgent rescue pancreatectomy without prior PTBD.\n\nConclusion: PTBD appears to be an effective complementary treatment method for clinically relevant biliopancreatic leakage after PD. Although promising, PTBD-related complications are common, with 50% requiring drain revision, and thus the treatment should be considered with caution.\n\n​​Trial Registration: Not applicable. This​ ​is a retrospective registry-based observational study.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgical Sciences, Gastrointestinal Surgery, Uppsala University, Uppsala, Sweden",
    "Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Souheil Reda"
    },
    {
      "affs": [
        0
      ],
      "name": "Jon Unosson"
    },
    {
      "affs": [
        0
      ],
      "name": "Christopher Månsson"
    },
    {
      "affs": [
        0
      ],
      "name": "Selma Kabous"
    },
    {
      "affs": [
        1
      ],
      "name": "Angeliki Dimopoulou Creusen"
    },
    {
      "affs": [
        0
      ],
      "name": "Srinivas Sanjeevi"
    },
    {
      "affs": [
        0
      ],
      "name": "Petter Fruhling"
    },
    {
      "affs": [
        0
      ],
      "name": "Bengt Isaksson"
    },
    {
      "affs": [
        0
      ],
      "name": "Jozef Urdzik"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5gxd5b1b64wjd.bib",
  "cited_by": 0,
  "doi": "10.1186/s12893-026-04313-0",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737911/",
  "id": "5gxd5b1b64wjd",
  "issns": [
    "1471-2482"
  ],
  "landing_url": "https://doi.org/10.1186/s12893-026-04313-0",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2715|Gallbladder and Bile Duct Disorders"
    ]
  ],
  "openalex": "W7225250047",
  "pdf_url": "https://link.springer.com/content/pdf/10.1186/s12893-026-04313-0.pdf",
  "pmcid": "PMC13737911",
  "pmid": "42983367",
  "published": "2026-11-04",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/5gxd5b1b64wjd.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:00Z",
      "native_id": "PMC13737911",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12893-026-04313-0"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2746|Minimally Invasive Surgical Techniques",
      "subfield": "surgery"
    }
  ],
  "title": "Percutaneous transhepatic biliary drainage as an effective complementary treatment option for clinically relevant biliopancreatic, pancreatic and biliary leakage after pancreaticoduodenectomy",
  "title_text": "Percutaneous transhepatic biliary drainage as an effective complementary treatment option for clinically relevant biliopancreatic, pancreatic and biliary leakage after pancreaticoduodenectomy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:00Z",
  "url": "https://research.draconitic.com/paper/5gxd5b1b64wjd",
  "venue": "BMC Surgery",
  "versions": []
}