{
  "abstract": "BackgroundCross-setting comparisons of carbapenem resistance may reflect clinical contexts and selective genomic sampling. We examined reproducibility on two independent scales.MethodsWe analysed retrospective adult cohorts from a Chinese hospital (n = 1,362) and the Medical Information Mart for Intensive Care IV (MIMIC-IV) v3.1 (n = 3,251), along with 26,417 publicly submitted clinical Pseudomonas aeruginosa BioSamples. Our clinical analyses compared susceptibility-defined carbapenem-resistant Pseudomonas aeruginosa (CRPA), evaluated outcomes, adjusting for associations, and conducted exploratory reciprocal model transport. Our genomic analyses examined annotated determinants, submission-year patterns, single-nucleotide polymorphism (SNP) clusters, and co-resistance, including cluster-weighted sensitivity analyses.ResultsCRPA proportions were 36.9 and 9.3% in the two institutions. Unadjusted in-hospital mortality and post-index hospital stay were higher among patients with CRPA. Adjusted association directions agreed for 13 of 18 covariates. Transported models showed modest discrimination (area under the curves [AUCs], 0.641 and 0.619) and marked miscalibration (calibration slopes, 0.45 and 0.52). Among the included public Biosamples, 60.7% carried a defined carbapenem-associated determinant and 24.4% carried an acquired carbapenemase. Chinese submissions had higher serine-carbapenemase positivity, whereas US submissions had higher metallo-β-lactamase and chromosomal-determinant positivity. The country OR for blaKPC changed from 8.04 in the full sample to 1.59 in the cluster-assigned weighted analysis; the OR for acquired carbapenemase changed from 1.32 to 0.67.ConclusionClinical associations may recur without supporting a reliable transported prediction. Genomic contrasts are sensitive to sampling and analysis population. These exploratory, unlinked findings neither establish causal effects nor estimate national prevalence; genomic results do not confirm phenotypic CRPA.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Original Research",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Cheng-En Li"
    },
    {
      "name": "Ying-Ying Shen"
    },
    {
      "name": "Ru-Qin Yi"
    },
    {
      "name": "Wei Chen"
    },
    {
      "name": "Ding Zhang"
    },
    {
      "name": "Sheng-Hui Miao"
    },
    {
      "name": "Zhi-Rong Zhang"
    },
    {
      "name": "Zhao-Kun Fan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5h0qbac16dg25.bib",
  "cited_by": 0,
  "doi": "10.3389/fmicb.2026.2002985",
  "fulltext_url": null,
  "id": "5h0qbac16dg25",
  "issns": [
    "1664-302X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.2002985",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "biology/microbiology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5h0qbac16dg25.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T06:20:15Z",
      "native_id": "10.3389/fmicb.2026.2002985",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.2002985"
    },
    {
      "first_seen": "2026-11-05T12:21:09Z",
      "native_id": "10.3389/fmicb.2026.2002985",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.2002985/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "feed-journal:biology/microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Clinical and public genomic comparisons of carbapenem resistance in Pseudomonas aeruginosa",
  "title_text": "Clinical and public genomic comparisons of carbapenem resistance in Pseudomonas aeruginosa",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T00:21:16Z",
  "url": "https://research.draconitic.com/paper/5h0qbac16dg25",
  "venue": "Frontiers in Microbiology",
  "versions": []
}