{
  "abstract": "We commend Duan et al. for examining laxative use after cardiac arrest. However, because follow-up began at return of spontaneous circulation, whereas exposure timing was not reported, the observed association may reflect both immortal time and treatment selection: patients who survived and recovered sufficiently may have been more likely to receive laxatives. A time-varying exposure defined by first administration, with landmark analysis as a sensitivity analysis, would better align treatment and risk time. The reported time-varying-effect model does not estimate the effect of initiating treatment on a particular day and, therefore, cannot support a 15-day treatment window. The findings should be framed as observational associations rather than evidence that laxatives improve survival.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jian Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Peihong Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongyi Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5ha8mas05dbfb.bib",
  "cited_by": 0,
  "doi": "10.1186/s40560-026-00950-y",
  "fulltext_url": "https://doi.org/10.1186/s40560-026-00950-y",
  "id": "5ha8mas05dbfb",
  "issns": [
    "2052-0492"
  ],
  "landing_url": "https://doi.org/10.1186/s40560-026-00950-y",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC86-88.9"
    ],
    [
      "openalex",
      "2711|Cardiac Arrest and Resuscitation"
    ]
  ],
  "openalex": "W7223227437",
  "pdf_url": "https://link.springer.com/content/pdf/10.1186/s40560-026-00950-y.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/5ha8mas05dbfb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:36Z",
      "native_id": "b6b94c342adc4d70a377f06f96a42db1",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s40560-026-00950-y"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2711|Cardiac Arrest and Resuscitation",
      "subfield": "general"
    }
  ],
  "title": "Laxative use after cardiac arrest: exposure timing, treatment selection, and outcome interpretation",
  "title_text": "Laxative use after cardiac arrest: exposure timing, treatment selection, and outcome interpretation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:36Z",
  "url": "https://research.draconitic.com/paper/5ha8mas05dbfb",
  "venue": "Journal of Intensive Care",
  "versions": []
}