{
  "abstract": "Parkinson's disease (PD) is driven in part by neuroinflammation. We investigated whether the transcription factor BCL11B contributes to dopaminergic neurodegeneration in this context. Transcriptome sequencing of MPTP-induced PD mice revealed BCL11B upregulation, which was confirmed in MPP⁺-treated MN9D cells, MPTP-lesioned mice, and dopaminergic neurons exposed to inflammatory conditioned medium. BCL11B knockdown attenuated dopaminergic neuron loss, reduced apoptosis, improved motor deficits, and partially blocked JAK2/STAT3 pathway activation in both inflammatory and MPTP-induced PD models. Mechanistically, BCL11B mediated neurotoxicity through the JAK2/STAT3 pathway, with acetylation modifications potentially modulating its activity. These findings establish BCL11B as a key regulator of neuroinflammation and dopaminergic survival in PD, and suggest that targeting BCL11B may offer a therapeutic approach for this neurodegenerative disease.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Wenwen Chen"
    },
    {
      "name": "Yejing Zhang"
    },
    {
      "name": "Xinrui Zhou"
    },
    {
      "name": "Jianan Yan"
    },
    {
      "name": "Yiming Song"
    },
    {
      "name": "Jiabing Shen",
      "orcid": "0000-0002-6434-7199"
    },
    {
      "name": "Xiaosu Gu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5hdc0g6j92641.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117833",
  "fulltext_url": "https://europepmc.org/articles/PMC13677406",
  "id": "5hdc0g6j92641",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03214-1",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Molecular biology"
    ],
    [
      "heading",
      "Neurology"
    ],
    [
      "heading",
      "Therapy"
    ],
    [
      "openalex",
      "2728|Parkinson's Disease Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7221024950",
  "pdf_url": "https://europepmc.org/articles/PMC13677406?pdf=render",
  "pmcid": "PMC13677406",
  "pmid": "42898226",
  "published": "2026-10-08",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/5hdc0g6j92641.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117833",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03214-1"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117833",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226032141"
    },
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898226",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898226"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "heading:Molecular biology",
      "subfield": "molecular-biology"
    },
    {
      "field": "medicine",
      "origin": "heading:Neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Targeting BCL11B-mediated JAK2/STAT3 activation: A novel therapeutic strategy for Parkinson’s disease",
  "title_text": "Targeting BCL11B-mediated JAK2/STAT3 activation: A novel therapeutic strategy for Parkinson’s disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/5hdc0g6j92641",
  "venue": "iScience",
  "versions": []
}