{
  "abstract": "Background/objectives\n\nThis study was conducted to prospectively evaluate quality of life (QoL), patient-reported outcomes, and geriatric domains during the first 3 months of first-line systemic therapy in older patients with de novo metastatic gastrointestinal cancers.Methods\n\nThis prospective longitudinal study included 90 patients aged ≥65 years receiving first-line chemotherapy-based systemic therapy. Assessments were performed at baseline, Month 1, and Month 3 using validated QoL, sleep, anxiety, cognitive, and nutritional instruments. The primary endpoint was change in EORTC QLQ-C30 Global Health Status/QoL from baseline to Month 3. Treatment tolerability, initial radiologic response, and exploratory survival outcomes were also assessed.Results\n\nMean Global Health Status/QoL increased from 68.1 at baseline to 71.0 at Month 3; the model-estimated mean change was +3.0 points (95% CI, -0.3 to 6.2; p = 0.071). Fatigue and appetite loss improved significantly, and normal nutritional status increased from 31.1% to 62.2% (p < 0.001). Clinically meaningful QoL improvement and deterioration occurred in 38.9% and 18.9%, respectively. Treatment intolerance occurred in 46.7%. Disease control was associated with more favorable QoL change than progressive disease (difference, 17.8 points; 95% CI, 6.0-29.7; FDR-adjusted p = 0.008). Baseline nutritional impairment (adjusted HR, 3.58) and poor sleep quality (adjusted HR, 3.30) were associated with shorter progression-free survival.Conclusions\n\nMean global QoL did not change significantly during the first 3 months, while several symptom and nutritional domains improved. More favorable QoL trajectories were observed with disease control, and baseline nutritional impairment and poor sleep quality were associated with shorter progression-free survival.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Oncology, Ankara Etlik City Hospital, Ankara 06170, Türkiye.",
    "Department of Medical Oncology, Ankara Etlik City Hospital, University of Health Sciences, Ankara 06170, Türkiye.",
    "Department of Medical Oncology, Gazi University, Ankara 06500, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hatice Ayyıldız Sevim",
      "orcid": "0000-0002-4072-5861"
    },
    {
      "affs": [
        1
      ],
      "name": "Hayriye Şahinli",
      "orcid": "0000-0002-1561-9346"
    },
    {
      "affs": [
        0
      ],
      "name": "Galip Can Uyar",
      "orcid": "0000-0002-0698-777X"
    },
    {
      "affs": [
        0
      ],
      "name": "Selahattin Çelik",
      "orcid": "0000-0002-5678-2633"
    },
    {
      "affs": [
        0
      ],
      "name": "Kadriye Bir Yücel"
    },
    {
      "affs": [
        2
      ],
      "name": "Osman Sütcüoğlu",
      "orcid": "0000-0003-3835-2741"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5hsrydek680a1.bib",
  "cited_by": 0,
  "doi": "10.3390/healthcare14203458",
  "fulltext_url": "https://europepmc.org/articles/PMC13704573",
  "id": "5hsrydek680a1",
  "issns": [
    "2227-9032"
  ],
  "landing_url": "https://europepmc.org/article/MED/42940505",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer survivorship and care"
    ]
  ],
  "openalex": "W7222074759",
  "pdf_url": "https://europepmc.org/articles/PMC13704573?pdf=render",
  "pmcid": "PMC13704573",
  "pmid": "42940505",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5hsrydek680a1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42940505",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42940505"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer survivorship and care",
      "subfield": "oncology"
    }
  ],
  "title": "Quality of Life and Patient-Reported Outcomes During First-Line Chemotherapy in Older Patients with De Novo Metastatic Gastrointestinal Cancers: A Prospective Longitudinal Study.",
  "title_text": "Quality of Life and Patient-Reported Outcomes During First-Line Chemotherapy in Older Patients with De Novo Metastatic Gastrointestinal Cancers: A Prospective Longitudinal Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/5hsrydek680a1",
  "venue": "Healthcare (Basel, Switzerland)",
  "versions": []
}