{
  "abstract": "ObjectiveThis study sought to create a CT-based clinical deep learning radiomics (CDLR) model to noninvasively differentiate between pyelocaliceal upper tract urothelial carcinoma (UTUC) and xanthogranulomatous pyelonephritis (XGP) preoperatively, aiding in personalized treatment decisions.MethodsA retrospective analysis included 161 patients with pathologically confirmed pyelocaliceal UTUC or XGP following surgery. Patients were randomly divided into a training cohort (n=112) and a validation cohort (n=49). Radiomics (Rad) features and deep learning (DL) features were extracted from the corticomedullary phase CT images. Combined with clinical features, and after feature selection, a logistic regression (LR) classifier was employed to construct the clinical model, the deep learning radiomics (DLR) model, and the clinical deep learning radiomics (CDLR) model. Model performance was evaluated using receiver operating characteristic (ROC) curves and decision curve analysis (DCA), with interpretability assessed by the shapley additive explanations (SHAP) method. In addition, the diagnostic performance of the models was compared with that of a radiologist with 5 years of experience in abdominal CT diagnosis.ResultsThe CDLR model achieved AUCs of 0.955 in the training cohort and 0.930 in the validation cohort. In the validation cohort, the CDLR model significantly outperformed the radiologist’s assessment (AUC: 0.930 vs. 0.695, P = 0.0006) and yielded numerically higher AUCs than the clinical model (0.823) and the DLR model (0.882). DCA indicated that the CDLR model provided the highest net clinical benefit. SHAP analysis demonstrated good model interpretability.ConclusionThe CDLR model integrating clinical, Rad, and DL features serves as an effective noninvasive tool for preoperative differentiation of pyelocaliceal UTUC and XGP, offering valuable reference for clinical decision-making.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Original Research",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Yi Feng"
    },
    {
      "name": "Yiheng Cheng"
    },
    {
      "name": "Jian Zeng"
    },
    {
      "name": "Junyu Lin"
    },
    {
      "name": "Hao Qin"
    },
    {
      "name": "Yizheng Yan"
    },
    {
      "name": "Zile Huang"
    },
    {
      "name": "Yongxian Wu"
    },
    {
      "name": "Xiao Liu"
    },
    {
      "name": "Fuxiang Fang"
    },
    {
      "name": "Linjian Mo"
    },
    {
      "name": "Wei Xu"
    },
    {
      "name": "Chengyang Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5hywqd952hs90.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1880690",
  "fulltext_url": null,
  "id": "5hywqd952hs90",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1880690",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "medicine/oncology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5hywqd952hs90.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:20:48Z",
      "native_id": "10.3389/fonc.2026.1880690",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1880690"
    },
    {
      "first_seen": "2026-11-02T12:24:06Z",
      "native_id": "10.3389/fonc.2026.1880690",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1880690/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "feed-journal:medicine/oncology",
      "subfield": "oncology"
    }
  ],
  "title": "CT-based clinical deep learning radiomics nomogram for preoperative differentiation of pyelocaliceal upper tract urothelial carcinoma and xanthogranulomatous pyelonephritis",
  "title_text": "CT-based clinical deep learning radiomics nomogram for preoperative differentiation of pyelocaliceal upper tract urothelial carcinoma and xanthogranulomatous pyelonephritis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T00:26:54Z",
  "url": "https://research.draconitic.com/paper/5hywqd952hs90",
  "venue": "Frontiers in Oncology",
  "versions": []
}