{
  "abstract": "The strain-release reactivity of azabicyclo[1.1.0]butanes (ABBs) offers a powerful entry to substituted azetidines, yet modular access to highly functionalized, allylic amine-containing frameworks remains underdeveloped. Here, we report a visible-light copper-catalyzed four-component coupling that effects 1,4-carboamination of aryl-substituted 1,3-dienes, assembling azetidines bearing a quaternary carbon center from dienes, aryl amines, and electrophiles using ABBs. Synergistic copper/photoredox catalysis unites strain-release generation of an azetidinyl radical with allylic C–N bond formation, delivering densely functionalized azetidines bearing an allylic amine in a single, redox-neutral operation. The reaction proceeds with high 1,4-regioselectivity and broad functional-group tolerance across diverse anilines, ABBs, dienes, and electrophiles, and operates under mild conditions. Biorelevant complex-molecule diversification, scalability, and downstream derivatization underscore the synthetic utility of the platform, while DFT calculations trace the 1,4-selectivity to stabilizing noncovalent interactions that favor benzylic C–N coupling and steric repulsion that disfavors the competing pathway.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Korea",
    "Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS) Daejeon 34141 Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yejin Koo",
      "orcid": "0000-0002-1985-0895"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Dongwoo Lee",
      "orcid": "0009-0008-1092-8626"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiyong Park",
      "orcid": "0000-0002-3225-4510"
    },
    {
      "affs": [
        1,
        0
      ],
      "name": "Sungwoo Hong",
      "orcid": "0000-0001-9371-1730"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5j2m1creh06dh.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc06133h",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13539498/",
  "id": "5j2m1creh06dh",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://doi.org/10.1039/d6sc06133h",
  "language": "en",
  "licence": "CC-BY-NC-3.0",
  "licence_label": "CC BY-NC 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7204262565",
  "pdf_url": null,
  "pmcid": "PMC13539498",
  "pmid": "42694688",
  "published": "2026-08-27",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/5j2m1creh06dh.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:44Z",
      "native_id": "PMC13539498",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc06133h"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Modular synthesis of functionalized azetidines through visible-light copper-catalyzed carboamination of 1,3-dienes with azabicyclo[1.1.0]butanes",
  "title_text": "Modular synthesis of functionalized azetidines through visible-light copper-catalyzed carboamination of 1,3-dienes with azabicyclo[1.1.0]butanes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:52Z",
  "url": "https://research.draconitic.com/paper/5j2m1creh06dh",
  "venue": "Chemical Science",
  "versions": []
}