{
  "abstract": "Background: Faecal microbiota transplantation (FMT) may improve glucose metabolism, but findings from randomised trials and previous meta-analyses are inconsistent. We evaluated the effects of FMT on glycaemic outcomes in adults with type 2 diabetes, prediabetes, insulin resistance or related metabolic disorders.\n\nMethods: We searched PubMed and Scopus for English-language randomised controlled trials published from January 2000 to May 2026. The primary outcome was change from baseline in HOMA-IR. Secondary outcomes included HbA1c, fasting glucose and clamp-derived peripheral insulin sensitivity. Random-effects meta-analyses used Paule–Mandel estimation with Hartung–Knapp–Sidik–Jonkman confidence intervals. Sensitivity analyses evaluated comparator type, data reconstruction, the assumed baseline–follow-up correlation and individual-study influence. Risk of bias was assessed using RoB 2.\n\nResults: The searches identified 887 records, and 18 studies met the eligibility criteria. Six trials involving 120 participants included to the primary analysis. FMT did not significantly reduce HOMA-IR compared with control (MD, −1.29; 95% CI [−3.04, 0.47]; I2 = 72%). The sensitivity analysis combining HOMA-IR and HOMA2-IR also produced a non-significant result (MD, −1.11; 95% CI [−2.50, 0.29]). HbA1c data were sparse and were not pooled across comparator types. Clamp-derived findings suggested a possible donor-phenotype effect but remained inconclusive. The certainty of evidence was very low for HOMA-IR and HbA1c and low for peripheral insulin sensitivity.\n\nConclusions: FMT did not demonstrate a clear benefit for glycaemic outcomes. The estimates were imprecise, heterogeneous and influenced by comparator design. Larger trials with standardised outcomes and predefined donor phenotypes are required.",
  "abstract_shown": true,
  "affiliations": [
    "Physiology Department, Danylo Halytsky Lviv National Medical University , ,",
    "Bogomolets National Medical University , ,",
    "Department of Therapy and Family Medicine, I. Horbachevsky Ternopil National Medical University , ,",
    "Department of Medical Rehabilitation, I. Horbachevsky Ternopil National Medical University , ,",
    "Department of Biochemistry and Pharmacology, Uzhhorod National University , ,",
    "Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University , ,"
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maryana Savytska"
    },
    {
      "affs": [
        1
      ],
      "name": "Viktoriya-Svitlana Halich"
    },
    {
      "affs": [
        1
      ],
      "name": "Liudmyla Kuzmenko"
    },
    {
      "affs": [
        2
      ],
      "name": "Iryna Halabitska"
    },
    {
      "affs": [
        3
      ],
      "name": "Iryna Kamyshna"
    },
    {
      "affs": [
        4
      ],
      "name": "Pavlo Petakh"
    },
    {
      "affs": [
        5
      ],
      "name": "Oleksandr Kamyshnyi"
    },
    {
      "affs": [
        1
      ],
      "name": "Nazarii Kobyliak"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5j39gkjm32jvj.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1983162",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719402/?tool=EBI",
  "id": "5j39gkjm32jvj",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13719402",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Systematic Review"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7222423192",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719402/pdf/?tool=EBI",
  "pmcid": "PMC13719402",
  "pmid": "42964097",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5j39gkjm32jvj.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13719402",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13719402"
    },
    {
      "first_seen": "2026-11-02T12:23:22Z",
      "native_id": "PMC13719402",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1983162"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Effects of faecal microbiota transplantation on glycaemic outcomes in adults with metabolic disorders: a systematic review and meta-analysis of randomised controlled trials",
  "title_text": "Effects of faecal microbiota transplantation on glycaemic outcomes in adults with metabolic disorders: a systematic review and meta-analysis of randomised controlled trials",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:28Z",
  "url": "https://research.draconitic.com/paper/5j39gkjm32jvj",
  "venue": "Frontiers in medicine",
  "versions": []
}