{
  "abstract": "Photochemical deracemization allows for the direct generation of enantiomerically pure or enriched compounds from their racemates employing a single chiral catalyst. In the present study, carboxylic acid amides (carboxamides) with a substituent in the α-position were investigated in a photochemical deracemization mediated by a chiral aromatic ketone. The catalyst displays a hydrogen bonding site which allows for a differentiation between the two enantiomers and operates by a reversible hydrogen atom transfer. It was found that α-alkoxy or α-amino substituents enable an efficient deracemization (up to 99.5 : 0.5 e.r.) due to a second intramolecular hydrogen bonding interaction locking a distinct substrate conformation.",
  "abstract_shown": true,
  "affiliations": [
    "Technische Universität München, School of Natural Sciences, Department of Chemistry and Catalysis Research Center Lichtenbergstrasse 4 85747 Garching Germany https://www.ch.nat.tum.de/en/oc1/home/"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maximilian Iglhaut",
      "orcid": "0009-0006-8190-1231"
    },
    {
      "affs": [
        0
      ],
      "name": "Biki Ghosh",
      "orcid": "0000-0002-1140-0347"
    },
    {
      "affs": [
        0
      ],
      "name": "Thorsten Bach",
      "orcid": "0000-0002-1342-0202"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5j4bzhwvhsf0f.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc05947c",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13555699/",
  "id": "5j4bzhwvhsf0f",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://doi.org/10.1039/d6sc05947c",
  "language": "en",
  "licence": "CC-BY-3.0",
  "licence_label": "CC BY 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Asymmetric Synthesis and Catalysis"
    ]
  ],
  "openalex": "W7212028971",
  "pdf_url": "https://pubs.rsc.org/sc/article-pdf/doi/10.1039/d6sc05947c/13771775/d6sc05947c.pdf",
  "pmcid": "PMC13555699",
  "pmid": "42719191",
  "published": "2026-09-09",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/5j4bzhwvhsf0f.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:45Z",
      "native_id": "PMC13555699",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc05947c"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Asymmetric Synthesis and Catalysis",
      "subfield": "organic"
    }
  ],
  "title": "Photochemical deracemization of α-chiral carboxamides mediated by inter- and intramolecular hydrogen bonding",
  "title_text": "Photochemical deracemization of α-chiral carboxamides mediated by inter- and intramolecular hydrogen bonding",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:53Z",
  "url": "https://research.draconitic.com/paper/5j4bzhwvhsf0f",
  "venue": "Chemical Science",
  "versions": []
}