{
  "abstract": "The dried fruits of Ligustrum lucidum Ait. are well-established in East Asian medicine for hepatoprotection. Given this ethnopharmacological precedent and their close taxonomic kinship, we hypothesized that the fruit polysaccharide of its horticultural congener, Ligustrum × vicaryi L. (LVFP), may confer analogous hepatic benefits. We assessed LVFP in a murine model of acute liver injury (ALI) induced by lipopolysaccharide and D-galactosamine (LPS/D-GalN) to test this hypothesis. LVFP pretreatment significantly mitigated hepatic pathological damage, normalized serum aminotransferases (AST, ALT), and reversed lipid peroxidation (reduced MDA, elevated SOD). Simultaneously, LVFP reduced pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and corrected lipid metabolic abnormalities (CHO, TG). To decode these phenotypic rescues, network pharmacology and molecular docking nominated a 10-gene hub signature (featuring KDR (binding energy = −8.65 kcal/mol), AKT1, GSK3B, and IL2). we further found that this signature—particularly KDR and PKM—robustly discriminates ALI from controls (AUC = 1.00; AUPR = 0.848), supporting its disease relevance. Collectively, these findings support our initial hypothesis that LVFP exerts multi-dimensional hepatoprotection.",
  "abstract_shown": true,
  "affiliations": [
    "School of Pharmacy, Jining Medical University, Rizhao 276826, China",
    "Institute of Immunology and Molecular Medicine, Jining Key Laboratory of Immunology, Jining Medical University, Jining 272067, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shu-Ling Liu",
      "orcid": "0000-0003-0807-6993"
    },
    {
      "affs": [
        1
      ],
      "name": "Hui Zhang",
      "orcid": "0000-0003-4123-3102"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian-An Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Run-Dong Lv"
    },
    {
      "affs": [
        0
      ],
      "name": "Shao-Jian Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Li-Tao Wang",
      "orcid": "0000-0002-3734-6676"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5j8zt2vwftqh2.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198805",
  "fulltext_url": "https://europepmc.org/articles/PMC13664983",
  "id": "5j8zt2vwftqh2",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/19/8805",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3004|Drug-Induced Hepatotoxicity and Protection"
    ]
  ],
  "openalex": "W7215067321",
  "pdf_url": "https://europepmc.org/articles/PMC13664983?pdf=render",
  "pmcid": "PMC13664983",
  "pmid": "42884047",
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/5j8zt2vwftqh2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27198805",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/19/8805"
    },
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42884047",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42884047"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3004|Drug-Induced Hepatotoxicity and Protection",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Ligustrum × vicaryi Fruit Polysaccharide Attenuates LPS/D-GalN-Induced Acute Liver Injury in Mice",
  "title_text": "Ligustrum × vicaryi Fruit Polysaccharide Attenuates LPS/D-GalN-Induced Acute Liver Injury in Mice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/5j8zt2vwftqh2",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}