{
  "abstract": "In January 2025, the Escherichia coli National Reference Center of France detected an outbreak of hemolytic uremic syndrome (HUS) in adults, caused by Shiga toxin-producing E. coli negative for locus of enterocyte effacement (LEE). The outbreak included 18 confirmed cases of E. coli infection, 5 probable or possible cases detected by in-house specific PCR, and 2 additional cases from Scotland and Belgium. Whole-genome sequencing identified the outbreak strain as O77 g:K92:H18, belonging to phylogroup D; the strain harbored the Shiga toxin 2 gene variant stx2d-073-C165-02 and a 134-kb plasmid with enterotoxin genes (estb-STb2 and eltAB). Epidemiologic investigation implicated raw-milk cheese as the contamination source. The strain represents a singular hybrid pathotype of Shiga toxin-producing and enterotoxigenic E. coli, expressing a K92 capsule with known cross-immunogenicity to Neisseria meningitidis group C, which could explain the absence of pediatric cases. Related strains have been identified in international databases since 2005, suggesting global emergence.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Justine de Larminat"
    },
    {
      "name": "Kevin La"
    },
    {
      "name": "Philippe Bidet"
    },
    {
      "name": "André Birgy"
    },
    {
      "name": "Sandrine Liguori"
    },
    {
      "name": "Pierre Phlipaux"
    },
    {
      "name": "Celine Courroux"
    },
    {
      "name": "Florence Crombé"
    },
    {
      "name": "Jorge Blanco"
    },
    {
      "name": "Paul Coppo"
    },
    {
      "name": "Antoine Dossier"
    },
    {
      "name": "Laurence Armand-Lefevre"
    },
    {
      "name": "François Xavier Weill"
    },
    {
      "name": "Carolina Silva Nodari"
    },
    {
      "name": "Gabrielle Jones"
    },
    {
      "name": "Aurelie Cointe"
    },
    {
      "name": "Stéphane Bonacorsi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5kdg79gssc6v2.bib",
  "cited_by": 4,
  "doi": "10.3201/eid3204.251417",
  "fulltext_url": null,
  "id": "5kdg79gssc6v2",
  "issns": [
    "1080-6040",
    "1080-6059"
  ],
  "landing_url": "https://pasteur.hal.science/pasteur-05801258v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1310|Escherichia coli research studies"
    ]
  ],
  "openalex": "W7152678794",
  "pdf_url": "https://pasteur.hal.science/pasteur-05801258/document",
  "pmcid": null,
  "pmid": "41986986",
  "published": "2026-10-15",
  "publisher": "Centers for Disease Control and Prevention",
  "ris": "https://research.draconitic.com/paper/5kdg79gssc6v2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:57Z",
      "native_id": "pasteur-05801258",
      "source": "hal",
      "url": "https://pasteur.hal.science/pasteur-05801258v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1310|Escherichia coli research studies",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Hemolytic Uremic Syndrome Outbreak in Adults and Shiga Toxin–Producing Escherichia coli Negative for Locus of Enterocyte Effacement, France, 2025",
  "title_text": "Hemolytic Uremic Syndrome Outbreak in Adults and Shiga Toxin–Producing Escherichia coli Negative for Locus of Enterocyte Effacement, France, 2025",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:57Z",
  "url": "https://research.draconitic.com/paper/5kdg79gssc6v2",
  "venue": "Emerging Infectious Diseases",
  "versions": []
}