{
  "abstract": "BACKGROUND AND PURPOSE: Age-related hearing loss (ARHL) and dementia are common chronic conditions among the elderly, significantly impacting the quality of life of older adults. Additionally, ARHL is an important and modifiable risk factor for dementia. This study aimed to investigate distinct patterns of cortical atrophy in patients with ARHL and mild cognitive impairment (MCI), comparing those with stable cognition (sMCI) with those who progressed to dementia (pMCI), using longitudinal MRI data. MATERIALS AND METHODS: We included a total of 93 participants from the Alzheimer's Disease Neuroimaging Initiative: 51 sMCI with normal hearing (sMCI+healthy control, group 1), 20 with sMCI with ARHL (sMCI+ARHL, group 2), and 22 with pMCI and ARHL (pMCI+ARHL, group 3). All subjects underwent 3 longitudinal T1-weighted MRI scans at approximately 1-year intervals. Cortical thickness was measured using FreeSurfer 6.0 in regions including the entorhinal cortex, parahippocampal gyrus, and temporal gyri. Repeated-measures ANOVA was used to compare atrophy rates, and receiver operating characteristic analysis evaluated the predictive value of significant regions. RESULTS: Group 3 showed substantial faster annual atrophy rates in the left entorhinal cortex, left middle temporal gyrus, and bilateral superior temporal gyri compared with group 1. Group 2 also exhibited faster atrophy in temporal regions than group 1. Receiver operating characteristic analysis demonstrated that combined use of these regions improved predictive accuracy for cognitive progression. CONCLUSIONS: Patients with ARHL with progressive cognitive decline exhibit accelerated atrophy in the auditory and early Alzheimer vulnerable regions. Combined cortical thickness measures may serve as a neuroimaging biomarker to predict cognitive progression in populations with ARHL.",
  "abstract_shown": true,
  "affiliations": [
    "From the Department of Radiology (L.H., F.C.), Hangzhou TCM Hospital Affiliated with Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China",
    "Department of Radiology (Q.Z., X.L., K.L., M.Z.), The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China",
    "Department of Radiology and Nuclear Medicine (X.L.), Xuanwu Hospital, Capital Medical University, Beijing, China",
    "Department of Radiology (J.L.), Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Luwei Hong",
      "orcid": "0000-0002-3591-2128"
    },
    {
      "affs": [
        1
      ],
      "name": "Qingze Zeng"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiao Luo"
    },
    {
      "affs": [
        1
      ],
      "name": "Kaicheng Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Xiaocao Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Jixuan Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Minming Zhang",
      "orcid": "0000-0003-0145-7558"
    },
    {
      "affs": [
        0
      ],
      "name": "Feng Cui"
    },
    {
      "name": "on behalf of Alzheimer’s Disease Neuroimaging Initiative"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5kfhf9rap2qta.bib",
  "cited_by": 0,
  "doi": "10.3174/ajnr.a9326",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738268/",
  "id": "5kfhf9rap2qta",
  "issns": [
    "0195-6108",
    "1936-959X"
  ],
  "landing_url": "https://doi.org/10.3174/ajnr.a9326",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Editor's Choice"
    ],
    [
      "heading",
      "Neurodegenerative Disorder Imaging"
    ],
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7147554349",
  "pdf_url": null,
  "pmcid": "PMC13738268",
  "pmid": "41916749",
  "published": "2026-11-06",
  "publisher": "American Society of Neuroradiology",
  "ris": "https://research.draconitic.com/paper/5kfhf9rap2qta.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:17Z",
      "native_id": "PMC13738268",
      "source": "pmc",
      "url": "https://doi.org/10.3174/ajnr.a9326"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Distinct Patterns of Cortical Atrophy Predict Cognitive Progression in Age-Related Hearing Loss: A Longitudinal MRI Study",
  "title_text": "Distinct Patterns of Cortical Atrophy Predict Cognitive Progression in Age-Related Hearing Loss: A Longitudinal MRI Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:17Z",
  "url": "https://research.draconitic.com/paper/5kfhf9rap2qta",
  "venue": "AJNR: American Journal of Neuroradiology",
  "versions": []
}