{
  "abstract": "The cellular complexity of adipose tissue plays a critical role in the pathogenesis of metabolic disease; however, mechanisms underlying adipose dysfunction remain poorly understood. Here, we constructed a single-nucleus and bulk transcriptomic atlas of human visceral adipose tissues from an ethnically homogeneous cohort with defined metabolic states: lean with normal glucose tolerance, obesity, and obesity with type 2 diabetes. Single-nucleus RNA sequencing (snRNA-seq) revealed a fibro-inflammatory subpopulation of adipose stem cells and adipocytes characterized by high THBS1 expression, which were enriched in individuals with obesity and obesity with type 2 diabetes compared to lean controls. Through complementary in vitro (human primary ASCs, THP-1 macrophages, and Matrigel-captured mature adipocytes), ex vivo (mouse and human visceral adipose tissue explants), and in vivo (gain-of-function and antibody-mediated neutralization) experiments, we demonstrated that THBS1 promoted adipose fibrosis and inflammation via macrophage-mediated TGFβ activation, impairing adipogenesis and adipocyte function. Inhibition of THBS1 attenuated fibro-inflammatory features in metabolically dysfunctional adipose tissues. Moreover, THBS1 levels in plasma and adipocytes correlated with metabolic traits, including BMI and HbA1c. Collectively, our study provides a cellular atlas of human visceral adipose tissues across metabolic disease states and identifies THBS1 as a key pathogenic driver and potential therapeutic target.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "Jisu Jung"
    },
    {
      "name": "Eun Seo Park",
      "orcid": "0000-0002-6790-5467"
    },
    {
      "name": "Na Keum Lee",
      "orcid": "0009-0004-1398-3365"
    },
    {
      "name": "Jung-Jae Lee"
    },
    {
      "name": "Uijin Juang"
    },
    {
      "name": "Qingzhi Huang",
      "orcid": "0000-0002-5717-1682"
    },
    {
      "name": "Young Suk Park"
    },
    {
      "name": "Hyung Joon Kim"
    },
    {
      "name": "Jung-Kwon Kim"
    },
    {
      "name": "Tae Jung Oh"
    },
    {
      "name": "Jae Myoung Suh",
      "orcid": "0000-0001-8097-4662"
    },
    {
      "name": "Jae Bum Kim",
      "orcid": "0000-0003-2337-6935"
    },
    {
      "name": "Joon Ho Moon",
      "orcid": "0000-0003-1897-0905"
    },
    {
      "name": "Jong Kyoung Kim",
      "orcid": "0000-0002-0257-0547"
    },
    {
      "name": "Sung Hee Choi",
      "orcid": "0000-0003-0740-8116"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5m5d67330w0n8.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77107-w",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710749/",
  "id": "5m5d67330w0n8",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-77107-w",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2713|Adipokines, Inflammation, and Metabolic Diseases"
    ]
  ],
  "openalex": "W7223690032",
  "pdf_url": "https://www.nature.com/articles/s41467-026-77107-w.pdf",
  "pmcid": "PMC13710749",
  "pmid": "42934245",
  "published": "2026-10-27",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/5m5d67330w0n8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-77107-w",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-77107-w"
    },
    {
      "first_seen": "2026-10-31T12:21:39Z",
      "native_id": "PMC13710749",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-77107-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Adipokines, Inflammation, and Metabolic Diseases",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Single-cell landscape of human adipose tissue reveals THBS1 as a potential driver of fibro-inflammation in metabolic disease",
  "title_text": "Single-cell landscape of human adipose tissue reveals THBS1 as a potential driver of fibro-inflammation in metabolic disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:39Z",
  "url": "https://research.draconitic.com/paper/5m5d67330w0n8",
  "venue": "Nature Communications",
  "versions": []
}