{
  "abstract": "Background\n\nBupivacaine has a variable block duration, while prilocaine provides a shorter, more predictable block but is less used in obstetrics. The goal is to compare the onset and duration of block induced by hyperbaric prilocaine 2% and hyperbaric bupivacaine 0.5% in intrathecal anesthesia for women undergoing elective cesarean sections (CS).Methods\n\nA prospective randomized and double-blind clinical trial included 144 individuals with uncomplicated pregnancies belonging to the American Society of Anesthesiologists physical status I or II. Patients were divided into two equal groups randomly: prilocaine group (Group A): received 60 mg hyperbaric prilocaine 2% (3 ml) intrathecally, and bupivacaine group (Group B): received 12.5 mg hyperbaric bupivacaine 0.5% (2.5 ml) intrathecally and 0.5 ml of normal saline. As 60 mg hyperbaric prilocaine 2% is equipotent to 12.5 mg of hyperbaric bupivacaine 0.5%. Onset time and duration of sensory and motor block recorded.Results\n\nMean arterial blood pressure was higher in Group A than in Group B at 5, 10, 15, and 20 min (P < 0.001), with no differences at baseline or 25-45 min. Intraoperative heart rate was substantially higher in Group B at 5, 10, 15, and 20 min, with comparable values at other time points. Visual analog scale (VAS) scores were higher in Group A at 1 h (P < 0.001) but substantially lower at 2 and 3 h (P < 0.001); VAS scores at 4 h were similar between groups.Conclusion\n\nHyperbaric prilocaine 2% provides faster onset, shorter sensory and motor block duration, more stable hemodynamics and less maternal hypotension than hyperbaric bupivacaine 0.5% in CS, with similar neonatal outcomes and side effects.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesia, Surgical ICU and Pain Management, Faculty of Medicine, Sohag University, Sohag, Egypt.",
    "Department of Anesthesia, Faculty of Medicine, Sohag University, Sohag, Egypt."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Elhadad Ali Mousa Hammam"
    },
    {
      "affs": [
        1
      ],
      "name": "Mostafa Mohamed Abd El Jaber Ahmed"
    },
    {
      "affs": [
        0
      ],
      "name": "Hala Mahmoud Hashim El Khaiat"
    },
    {
      "affs": [
        0
      ],
      "name": "Khaled Abdelfattah Mohamed Abdelfattah"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5m71e5t5j6zbz.bib",
  "cited_by": 0,
  "doi": "10.4103/sja.sja_360_26",
  "fulltext_url": "https://europepmc.org/articles/PMC13719072",
  "id": "5m71e5t5j6zbz",
  "issns": [
    "1658-354X",
    "0975-3125"
  ],
  "landing_url": "https://europepmc.org/article/MED/42960029",
  "language": "eng",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2746|Anesthesia and Pain Management"
    ]
  ],
  "openalex": "W7215126347",
  "pdf_url": "https://europepmc.org/articles/PMC13719072?pdf=render",
  "pmcid": "PMC13719072",
  "pmid": "42960029",
  "published": "2026-10-01",
  "publisher": "Wolters Kluwer -- Medknow Publications",
  "ris": "https://research.draconitic.com/paper/5m71e5t5j6zbz.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:52Z",
      "native_id": "MED:42960029",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960029"
    },
    {
      "first_seen": "2026-11-02T12:22:58Z",
      "native_id": "PMC13719072",
      "source": "pmc",
      "url": "https://doi.org/10.4103/sja.sja_360_26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Anesthesia and Pain Management",
      "subfield": "surgery"
    }
  ],
  "title": "A comparative study between hyperbaric prilocaine 2% versus hyperbaric bupivacaine 0.5% for intrathecal anesthesia in cesarean section.",
  "title_text": "A comparative study between hyperbaric prilocaine 2% versus hyperbaric bupivacaine 0.5% for intrathecal anesthesia in cesarean section.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:58Z",
  "url": "https://research.draconitic.com/paper/5m71e5t5j6zbz",
  "venue": "Saudi journal of anaesthesia",
  "versions": []
}