{
  "abstract": "Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) coinfection is associated with accelerated liver disease, but whether coinfection is associated with newly documented social determinants of health (SDoH) is unclear. We conducted a retrospective cohort study using TriNetX across 110 U.S. healthcare organizations (2010-2026). We propensity score matched adults with HIV/HBV to adults with HIV or HBV monoinfection. We organized newly documented SDoH indicators using a dynamic individual-level framework with four clinically recognized domains of social disadvantage: material vulnerability, healthcare access and engagement, interpersonal adversity, and psychosocial vulnerability. Matched cohorts included 10,071 HIV/HBV-HIV pairs and 9,659 HIV/HBV-HBV pairs (mean age, 47 years; 79% male; 66% non-White; median follow-up, 3.3 years). Over 178,900 person-years, HIV/HBV was associated with higher risk of the primary SDoH composite compared with HIV (11.5% vs 9.7%; incidence rate, 2.50 vs 1.97 per 100 person-years; hazard ratio [HR], 1.25; 95% confidence interval [CI], 1.15-1.37) and HBV (11.0% vs 6.4%; incidence rate, 2.39 vs 1.67; HR, 1.50; 95% CI, 1.35-1.67). HIV/HBV was also associated with higher material vulnerability and healthcare access and engagement composites in both comparisons, including housing instability, food insecurity, financial insecurity, insurance instability, and care disengagement/nonadherence (HR range, 1.22-3.33 vs HIV; 1.31-1.94 vs HBV). In the HBV comparison, HIV/HBV was additionally associated with interpersonal adversity, primary support stressors, and violence or victimization (HR range, 1.36-2.16). Findings were robust across sensitivity analyses. HIV/HBV was associated with more newly documented SDoH than monoinfection, supporting dynamic SDoH assessment.",
  "abstract_shown": true,
  "affiliations": [
    "Case Western Reserve University"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "G. Yendewa"
    },
    {
      "name": "T. Chengsupanimit"
    },
    {
      "name": "A. Dehghani"
    },
    {
      "name": "A. Ahmed"
    },
    {
      "name": "A. Mohareb"
    },
    {
      "name": "M. Freeman"
    },
    {
      "name": "C. Cohen"
    },
    {
      "name": "I. Ofotokun"
    },
    {
      "name": "K. Dube"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5mfjm1j5pp4hc.bib",
  "cited_by": 1,
  "doi": "10.64898/2026.08.31.26361856",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.08.31.26361856v1.full",
  "id": "5mfjm1j5pp4hc",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.08.31.26361856v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "hiv aids"
    ],
    [
      "openalex",
      "2725|HIV/AIDS Research and Interventions"
    ]
  ],
  "openalex": "W7206181377",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.08.31.26361856v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5mfjm1j5pp4hc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "10.64898/2026.08.31.26361856",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.08.31.26361856v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:hiv aids",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Social Determinants of Health in HIV/HBV Coinfection Compared with HIV and HBV Monoinfection: A Framework for Dynamic Social Vulnerability",
  "title_text": "Social Determinants of Health in HIV/HBV Coinfection Compared with HIV and HBV Monoinfection: A Framework for Dynamic Social Vulnerability",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:35Z",
  "url": "https://research.draconitic.com/paper/5mfjm1j5pp4hc",
  "venue": "medRxiv",
  "versions": []
}