{
  "abstract": "T-cell immunity orchestrates host defense against pathogens, tumor surveillance, and autoimmune tolerance, yet the full repertoire of post-transcriptional regulators shaping T-cell fate remains incompletely defined. The DExD/H-box RNA helicase family, best known for canonical RNA-metabolic and nucleic-acid-sensing activities, has emerged as multifaceted modulators governing multiple key steps of T-cell biology. Beyond acting as pattern-recognition sensors in antigen-presenting cells, these helicases exert cell-intrinsic control over T-cell receptor signaling, thymic development, helper-subset polarization, cytotoxic CD8 ⁺ T-cell effector-memory programming, and regulatory T-cell lineage commitment via chromatin remodeling, pre-mRNA splicing, translational control and transposable-element homeostasis. Accumulating pre-clinical evidence highlights their potential translational value as biomarkers or therapeutic targets, pending further validation for autoimmunity, infection, cancer and transplant rejection. Nevertheless, major gaps persist, including poorly resolved T-cell-specific functions for most helicase paralogs, obscure molecular underpinnings of their non-canonical activities, and challenges in achieving isoform-selective pharmacological targeting. Here we synthesize current mechanistic insights of DExD/H-box helicases in T-cell immunity, discuss their translational opportunities, and outline critical outstanding questions to guide future functional and therapeutic investigations.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, Peking University People’s Hospital",
    "Peking University Institute of Organ Transplantation",
    "Hebei North University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Wenlin Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Kun Wu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tiancheng Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wenbo Yang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yongjie Zhang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zhao Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jiankang Dong"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yujie Yang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "He Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jianfei Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Weiyu Zhang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Qiang Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5mjpjda403m2v.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.2005330",
  "fulltext_url": null,
  "id": "5mjpjda403m2v",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.2005330/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5mjpjda403m2v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:19Z",
      "native_id": "10.3389/fimmu.2026.2005330",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.2005330/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Research progress of the DExD/H-Box RNA helicase family in T cell immune responses",
  "title_text": "Research progress of the DExD/H-Box RNA helicase family in T cell immune responses",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:20:59Z",
  "url": "https://research.draconitic.com/paper/5mjpjda403m2v",
  "venue": "Frontiers in Immunology",
  "versions": []
}