{
  "abstract": "Ionizing radiation exposure leads to inflammation and tissue damage, in which macrophage extracellular traps (METs) may play a role. Effective strategies to mitigate inflammation caused by radiation-induced METs are needed. We have recently developed a novel opsonic peptide, OP18, that targets multiple damage-associated molecular patterns (DAMPs) and enhances their clearance by macrophages. Because METs contain DAMPs, including histone H3 and high-mobility group box 1 protein (HMGB1), we hypothesize that OP18 promotes the clearance of radiation-induced METs and thereby reduces inflammation. In vitro studies were conducted using macrophages exposed to radiation and METs, with or without OP18 treatment. METs uptake, endo-lysosomal trafficking, integrin involvement, mitochondrial function, NF-κB activation, and cytokine release were assessed. OP18 significantly enhances MET uptake by macrophages, an effect that is mediated by α v β ₃ -integrin and involves the endo-lysosomal trafficking. This enhanced clearance by OP18 alleviates METs-induced mitochondrial stress and restores metabolic function (ATP production, basal/maximal respiration) in macrophages. Furthermore, OP18 treatment exhibits a trend towards decreasing METs-induced NF-κB activation while increasing the release of anti-inflammatory cytokine IL-10. OP18 represents a novel therapeutic approach to mitigate radiation-induced inflammation by promoting the efficient clearance of pro-inflammatory METs, thereby restoring cellular homeostasis and dampening inflammatory signaling.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research",
    "Departments of Surgery and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yongchan Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Gaifeng Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Dilara Aylar"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Monowar Aziz"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ping Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5mkfcyb95arrg.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1970645",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13696247/?tool=EBI",
  "id": "5mkfcyb95arrg",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1970645/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Neutrophil, Myeloperoxidase and Oxidative Mechanisms"
    ]
  ],
  "openalex": "W7221471995",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13696247/pdf/?tool=EBI",
  "pmcid": "PMC13696247",
  "pmid": null,
  "published": "2026-10-12",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5mkfcyb95arrg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1970645",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1970645/full"
    },
    {
      "first_seen": "2026-10-30T12:21:25Z",
      "native_id": "PMC:PMC13696247",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13696247"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Neutrophil, Myeloperoxidase and Oxidative Mechanisms",
      "subfield": "immunology"
    }
  ],
  "title": "An opsonic peptide promotes radiation-induced macrophage extracellular trap clearance to alleviate inflammation",
  "title_text": "An opsonic peptide promotes radiation-induced macrophage extracellular trap clearance to alleviate inflammation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:25Z",
  "url": "https://research.draconitic.com/paper/5mkfcyb95arrg",
  "venue": "Frontiers in Immunology",
  "versions": []
}