{
  "abstract": "Hydrophobic molecules are generally difficult to incorporate into aqueous hydrogels because of their poor water solubility. In this study, a cyclodextrin (CD)-containing tannic acid-lipoic acid (TA-LA) hydrogel was developed using lipoic acid-modified β-cyclodextrin (LACD). LACD retained the host-guest recognition ability of the cyclodextrin cavity after lipoic acid modification and was successfully incorporated into the TA-LA hydrogel without interfering with gel formation. Using Nile Red (NR) as a model hydrophobic molecule, the LACD-containing hydrogel showed higher NR encapsulation efficiency and greater cyclodextrin retention than the hydrogel containing unmodified β-cyclodextrin. The LACD-containing hydrogel also exhibited reduction-responsive NR release in the presence of dithiothreitol (DTT). These results show that LACD can be incorporated into the TA-LA hydrogel while retaining the host-guest recognition ability of the cyclodextrin cavity and can be used for reduction-responsive release of NR.",
  "abstract_shown": true,
  "affiliations": [
    "Environmental Symbiotic System Major, Graduate School, Nippon Institute of Technology, Miyashiro 345-8501, Saitama, Japan.",
    "Department of Mechanical Engineering, Nippon Institute of Technology, Miyashiro 345-8501, Saitama, Japan.",
    "Department of Chemistry, Shibaura Institute of Technology, Fukasaku, Minumaku, Saitama-City 337-8570, Saitama, Japan.",
    "Research & Development Center for Advanced Materials and Technology, Nippon Institute of Technology, Miyashiro 345-8501, Saitama, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuzheng Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Kazuya U Kobayashi"
    },
    {
      "affs": [
        2
      ],
      "name": "Akihiko Hatano"
    },
    {
      "affs": [
        3
      ],
      "name": "Manabu Suzuki"
    },
    {
      "affs": [
        0
      ],
      "name": "Kenichi Niikura"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5mkr8ax8yaq9b.bib",
  "cited_by": 0,
  "doi": "10.3390/gels12100868",
  "fulltext_url": "https://europepmc.org/articles/PMC13704123",
  "id": "5mkr8ax8yaq9b",
  "issns": [
    "2310-2861"
  ],
  "landing_url": "https://europepmc.org/article/MED/42929903",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1313|Hydrogels: synthesis, properties, applications"
    ]
  ],
  "openalex": "W7214277520",
  "pdf_url": "https://europepmc.org/articles/PMC13704123?pdf=render",
  "pmcid": "PMC13704123",
  "pmid": "42929903",
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5mkr8ax8yaq9b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929903",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929903"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Hydrogels: synthesis, properties, applications",
      "subfield": "general"
    }
  ],
  "title": "Cyclodextrin-Containing Tannic Acid-Lipoic Acid Hydrogels for the Loading and Reduction-Responsive Release of Nile Red.",
  "title_text": "Cyclodextrin-Containing Tannic Acid-Lipoic Acid Hydrogels for the Loading and Reduction-Responsive Release of Nile Red.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/5mkr8ax8yaq9b",
  "venue": "Gels (Basel, Switzerland)",
  "versions": []
}