{
  "abstract": "SUMMARY: Disruption of circadian glucocorticoid (GC) rhythms is associated with chronic stress and obesity, yet its metabolic signature remains poorly defined. Using a physiological mouse model, we show that the liver is largely protected from pathological steatosis despite profound obesity and hyperinsulinemia. We identify a unique redistribution of insulin resistance: rhythm disruption does not globally impair insulin action as occurs in diet-induced obesity. Instead, skeletal muscle develops severe insulin resistance while adipose and hepatic tissues remain functionally insulin responsive. This preserved sensitivity allows the adipose tissue to act as a metabolic reservoir, utilizing sustained hyperinsulinemia to sequester lipids and shield the liver from toxic fatty-acid flux. These findings reveal that GC-rhythm disruption uncouples obesity from hepatic steatosis by redistributing insulin action from skeletal muscle to adipose tissue and liver. Thus, GC-rhythm disruption and high-fat diet are independent and additive drivers of adiposity with divergent hepatic effects.",
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  "affiliations": [
    "Department of Biochemistry and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA",
    "These authors contributed equally",
    "Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA",
    "Department of Pediatrics, NewYork-Presbyterian Hospital/Weill Cornell Medicine, New York, NY 10021, USA",
    "Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA",
    "Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA",
    "Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA",
    "Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA",
    "Gale and Ira Drukier Institute for Children’s Health, Weill Cornell Medicine, New York, NY 10021, USA",
    "Lead contact"
  ],
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  "author_total": 22,
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      "name": "Sanjeev Sharma"
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      "name": "Anthony Narciso"
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      "name": "Lucas Paulo Jacinto Saavedra"
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      "name": "Jijo Wilson"
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      "name": "Louise Lantier"
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      "name": "Erin Kilkenny"
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      "name": "Ahsan Uddin"
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      "name": "Carolina E. Echeverria"
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      "name": "Katherine R. Ferrick"
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      "name": "Isaac Nathoo"
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      "name": "Jonathan Gao"
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      "name": "Edmund D. Kapelczak"
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      "name": "Marcus D. Goncalves"
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      "name": "Timothy E. McGraw"
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    {
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        8,
        9
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      "name": "Mary N. Teruel"
    }
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  "bibtex": "https://research.draconitic.com/paper/5n17emcz41dt9.bib",
  "cited_by": 0,
  "doi": "10.1016/j.celrep.2026.117926",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715039/",
  "id": "5n17emcz41dt9",
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  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
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  "pmcid": "PMC13715039",
  "pmid": "42715103",
  "published": "2026-09-08",
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  "title": "Disrupted glucocorticoid rhythms selectively induce severe skeletal muscle insulin resistance and uncouple obesity from hepatic steatosis",
  "title_text": "Disrupted glucocorticoid rhythms selectively induce severe skeletal muscle insulin resistance and uncouple obesity from hepatic steatosis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:25Z",
  "url": "https://research.draconitic.com/paper/5n17emcz41dt9",
  "venue": "Cell reports",
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}