{
  "abstract": "Introduction: Hydroxychloroquine (HCQ) has immunomodulatory and anti-inflammatory properties that may provide additional benefit in chronic proteinuric glomerulopathy (CGN). This study aimed to evaluate the short-term effects of adjunctive HCQ on proteinuria and inflammatory biomarkers in patients with stable CGN receiving optimized supportive therapy.\n\nMethods: In this single-center, double-blind, placebo-controlled proof-of-concept randomized trial, 43 patients with CGN (urine protein-to-creatinine ratio of ≥0.5 g/g and estimated glomerular filtration rate [eGFR] of >20 mL/min/1.73 m2) were randomized to receive eGFR-adjusted HCQ (n = 21) or placebo (n = 22) for 4 months. The primary outcome was change in proteinuria; secondary outcomes included interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP), eGFR, and safety.\n\nResults: After 4 months, the median percentage change in proteinuria was −27.9% (IQR, −55.1 to −15.5) with HCQ versus +20.7% (IQR, −6.9 to +45.4) with placebo. In mixed-effects maximum-likelihood regression adjusted for systolic blood pressure, HCQ was associated with a greater reduction in proteinuria than placebo (β, −118.55; 95% CI, −208.07 to −29.03; p = 0.009). A ≥30% reduction in proteinuria occurred more frequently with HCQ than placebo (50.0% vs. 14.3%; p = 0.014). IL-6 and hsCRP were also reduced with HCQ. No significant between-group difference in eGFR or serious adverse events was observed.\n\nConclusion: Adjunctive HCQ was associated with a short-term reduction in proteinuria in patients with stable chronic proteinuric glomerulopathy receiving optimized supportive therapy. Exploratory reductions in IL-6 and hsCRP were also observed. These proof-of-concept findings support further evaluation of HCQ in larger, longer, biopsy-based, disease-specific randomized trials.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Thitirat Supasil"
    },
    {
      "affs": [
        0
      ],
      "name": "Paramat Thimachai"
    },
    {
      "affs": [
        0
      ],
      "name": "Ouppatham Supasyndh"
    },
    {
      "affs": [
        0
      ],
      "name": "Bancha Satirapoj",
      "orcid": "0000-0002-8881-0942"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5nckgsy77a7hn.bib",
  "cited_by": 0,
  "doi": "10.1159/gdz/acyag005",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13719201/",
  "id": "5nckgsy77a7hn",
  "issns": [
    "2673-3625",
    "2673-3633"
  ],
  "landing_url": "https://doi.org/10.1159/gdz/acyag005",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Nephrology"
    ],
    [
      "openalex",
      "2727|Renal Diseases and Glomerulopathies"
    ]
  ],
  "openalex": "W7215098023",
  "pdf_url": "https://karger.com/gdz/article-pdf/doi/10.1159/gdz/acyag005/4589546/000554448.pdf",
  "pmcid": "PMC13719201",
  "pmid": "42960384",
  "published": "2026-09-29",
  "publisher": "Karger Publishers",
  "ris": "https://research.draconitic.com/paper/5nckgsy77a7hn.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:23:04Z",
      "native_id": "PMC13719201",
      "source": "pmc",
      "url": "https://doi.org/10.1159/gdz/acyag005"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Renal Diseases and Glomerulopathies",
      "subfield": "general"
    }
  ],
  "title": "Effect of Hydroxychloroquine on Proteinuria and Inflammatory Markers in Chronic Glomerulopathy: A Proof-of-Concept Randomized Controlled Trial (HCQ-CGN Trial)",
  "title_text": "Effect of Hydroxychloroquine on Proteinuria and Inflammatory Markers in Chronic Glomerulopathy: A Proof-of-Concept Randomized Controlled Trial (HCQ-CGN Trial)",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:23:04Z",
  "url": "https://research.draconitic.com/paper/5nckgsy77a7hn",
  "venue": "Glomerular Diseases",
  "versions": []
}