{
  "abstract": "Dendritic cells (DCs) play a critical role in modulating immune responses and tissue homeostasis. While immature DCs have been shown to enhance cell proliferation, the function of mature DCs (mDCs) in connective tissue biology remains less well understood. Here, we report that mDCs exert a potent inhibitory effect on tenocytes (TCs) and fibroblasts (FBs), suppressing both cell proliferation and type I collagen production. Using in vitro co-culture and supernatant transfer experiments, we demonstrate that this suppression is primarily mediated by soluble factors. Further mechanistic analysis revealed that type I interferons (IFN-α, IFN-β, IFN-ω), produced by mDCs upon LPS-induced maturation, are key mediators of these effects. Neutralization of the type I IFN signaling pathway restored both proliferation and collagen synthesis in TCs and FBs, confirming the central role of IFN signaling. Our findings suggest that mDCs may contribute to impaired tissue regeneration in inflammatory tendon pathologies.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Medical University of Vienna",
    "Department of Dermatology, Medical University of Vienna",
    "Department of Medicine, Surgery and Dentistry, University of Salerno"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Veronica Pinnarò"
    },
    {
      "affs": [
        0
      ],
      "name": "Sonia V. Rodriguez Monje"
    },
    {
      "affs": [
        0
      ],
      "name": "Sarojinidevi Künig"
    },
    {
      "affs": [
        0
      ],
      "name": "Nico Lamot"
    },
    {
      "affs": [
        1
      ],
      "name": "Adelheid Elbe-Bürger"
    },
    {
      "affs": [
        2
      ],
      "name": "Maria Camilla Ciardulli"
    },
    {
      "affs": [
        2
      ],
      "name": "Giovanna Della Porta"
    },
    {
      "affs": [
        0
      ],
      "name": "Johannes Stöckl"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5nd52t010y29b.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1933065",
  "fulltext_url": "https://europepmc.org/articles/PMC13713368",
  "id": "5nd52t010y29b",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1933065/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2732|Tendon Structure and Treatment"
    ]
  ],
  "openalex": "W7221747194",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1933065/pdf",
  "pmcid": "PMC13713368",
  "pmid": "42952626",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5nd52t010y29b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1933065",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1933065/full"
    },
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42952626",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952626"
    },
    {
      "first_seen": "2026-10-31T12:23:55Z",
      "native_id": "PMC13713368",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1933065"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2732|Tendon Structure and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Mature dendritic cells suppress tenocyte and fibroblast function via type I interferon signaling",
  "title_text": "Mature dendritic cells suppress tenocyte and fibroblast function via type I interferon signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:03Z",
  "url": "https://research.draconitic.com/paper/5nd52t010y29b",
  "venue": "Frontiers in Immunology",
  "versions": []
}