{
  "abstract": "Focal segmental glomerulosclerosis (FSGS), a major cause of end-stage renal disease, involves podocyte injury and immune dysregulation. We integrated GEO transcriptomic datasets to identify 839 differentially expressed genes and 33 differential mitophagy-related genes via differential expression analysis and weighted gene co-expression network analysis. Machine learning identified six candidate diagnostic biomarkers, SLIRP, BLVRB, ATP6V1F, COX5B, TMEM14A, and TRMT112, with moderate-to-good discriminatory capacity across cohorts. xCell analysis revealed extensive renal immune remodeling in FSGS with expanded pro-inflammatory cells, diminished naive T cells and Tregs, and tight correlations between hub genes and immune profiles. Single-cell RNA-sequencing analysis suggested a trend of downregulation of hub genes in FSGS podocytes, alongside suppressed transcriptomic signatures of mitochondrial energy metabolism and mitophagy-related pathways. qRT-PCR and western blot validated their downregulation at the whole-renal-tissue level in FSGS mouse models. These six genes may serve as diagnostic candidates and provide research clues for exploring mitophagy mechanisms in FSGS.",
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  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Jianan Ma"
    },
    {
      "name": "Tianshuai Ma"
    },
    {
      "name": "Yongrui Zhang"
    },
    {
      "name": "Haijian Wei",
      "orcid": "0009-0000-8675-2083"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5nj4fcchz2kzk.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.118015",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720624/?tool=EBI",
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  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03398-5",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Clinical genetics"
    ],
    [
      "heading",
      "Omics"
    ],
    [
      "openalex",
      "2727|Renal Diseases and Glomerulopathies"
    ]
  ],
  "openalex": "W7223337610",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720624/pdf/?tool=EBI",
  "pmcid": "PMC13720624",
  "pmid": "42964448",
  "published": "2026-10-23",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/5nj4fcchz2kzk.ris",
  "sources": [
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      "first_seen": "2026-10-30T12:17:16Z",
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      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226033985"
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      "url": "https://europepmc.org/article/PMC/PMC13720624"
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    {
      "first_seen": "2026-11-03T12:21:28Z",
      "native_id": "PMC13720624",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.isci.2026.118015"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Renal Diseases and Glomerulopathies",
      "subfield": "general"
    }
  ],
  "title": "Identification of mitophagy-related genes with diagnostic value in focal segmental glomerulosclerosis using bioinformatics analysis",
  "title_text": "Identification of mitophagy-related genes with diagnostic value in focal segmental glomerulosclerosis using bioinformatics analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:28Z",
  "url": "https://research.draconitic.com/paper/5nj4fcchz2kzk",
  "venue": "iScience",
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}