{
  "abstract": "Glioblastoma is a highly aggressive brain tumour driven by therapy-resistant glioblastoma stem cells (GSCs) that switch between dormant and proliferative states through poorly defined programs. In this study, we identify SAT1, encoding the rate-limiting polyamine-catabolic enzyme SSAT1, as enriched in quiescent GSCs, linking metabolic rewiring to dormancy. Pharmacologic induction of SSAT1 with the polyamine analogue N1,N11-Diethylnorspermine (DENSpm) triggers a chemoprotective, reversible growth arrest in patient-derived GSCs, independent of stemness, differentiation or senescence. SAT1-induced dormancy coincides with reduced eIF5A hypusination and global protein translation, and a marked rise in double-stranded RNA that activates type I interferon signalling. Knocking down the mitochondrial antiviral-signalling protein, essential for antiviral innate immunity, partially reverses this growth arrest, establishing viral mimicry as functionally required for dormancy. Single-cell and cohort analyses across GSCs and neural stem cells demonstrate that susceptibility to metabolically induced quiescence is set by an intrinsic inflammatory tone and lysosomal dependency, defining a context-dependent metabolic-immune axis which can be targeted to prevent GBM progression.",
  "abstract_shown": true,
  "affiliations": [
    "The Hospital for Sick Children"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "C. Chesnelong"
    },
    {
      "name": "K. Desai"
    },
    {
      "name": "C. S. Charton"
    },
    {
      "name": "M. Kushida"
    },
    {
      "name": "C. Yu"
    },
    {
      "name": "P. Guilhamon"
    },
    {
      "name": "L. Lee"
    },
    {
      "name": "S. Agnihotri"
    },
    {
      "affs": [
        0
      ],
      "name": "P. B. Dirks"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5nxtgef5w61cw.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.01.755088",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.01.755088v1.full",
  "id": "5nxtgef5w61cw",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.01.755088v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cancer biology"
    ],
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7220462681",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.01.755088v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5nxtgef5w61cw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:02Z",
      "native_id": "10.64898/2026.10.01.755088",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.01.755088v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:cancer biology",
      "subfield": "oncology"
    }
  ],
  "title": "Metabolic rewiring induces a viral mimicry-mediated quiescence in glioblastoma",
  "title_text": "Metabolic rewiring induces a viral mimicry-mediated quiescence in glioblastoma",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:02Z",
  "url": "https://research.draconitic.com/paper/5nxtgef5w61cw",
  "venue": "bioRxiv",
  "versions": []
}