{
  "abstract": "Background: Extramammary Paget's disease (EMPD) is a rare cutaneous in situ adenocarcinoma sometimes associated with invasive malignancy that may evolve to metastatic disease. HER2 alterations have been reported in aggressive cases and may be targetable. Case presentation: amplification who progressed after local therapies, surgery, radiotherapy and trastuzumab ± paclitaxel. Off-label trastuzumab-deruxtecan (T-DXd) was started as second-line systemic therapy with marked extracranial and intracranial responses and acceptable toxicity. Conclusion: This case supports consideration of HER2-directed antibody-drug conjugates in HER2-positive EMPD when standard options are exhausted.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Myrtille Thomas"
    },
    {
      "name": "Mojgan Devouassoux-Shisheboran"
    },
    {
      "name": "Jonathan Lopez"
    },
    {
      "name": "Pierre Descargues"
    },
    {
      "name": "Witold Gertych"
    },
    {
      "name": "Ionela Caraivan"
    },
    {
      "name": "Benoit You"
    },
    {
      "name": "Julien Péron"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5p67ecv45hfhy.bib",
  "cited_by": 0,
  "doi": "10.1016/j.gore.2026.102213",
  "fulltext_url": null,
  "id": "5p67ecv45hfhy",
  "issns": [
    "2352-5789"
  ],
  "landing_url": "https://hal.science/hal-05799782v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.spee"
    ],
    [
      "openalex",
      "2708|Cancer and Skin Lesions"
    ]
  ],
  "openalex": "W7213442332",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2352578926001931/pdf",
  "pmcid": null,
  "pmid": "42824666",
  "published": "2026-10-14",
  "publisher": "Society of Gynecologic Oncology",
  "ris": "https://research.draconitic.com/paper/5p67ecv45hfhy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:57Z",
      "native_id": "hal-05799782",
      "source": "hal",
      "url": "https://hal.science/hal-05799782v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Dramatic response to trastuzumab-deruxtecan in metastatic HER2-overexpressing vulvar extramammary Paget's disease: A case report",
  "title_text": "Dramatic response to trastuzumab-deruxtecan in metastatic HER2-overexpressing vulvar extramammary Paget's disease: A case report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:57Z",
  "url": "https://research.draconitic.com/paper/5p67ecv45hfhy",
  "venue": "Gynecologic Oncology Reports",
  "versions": []
}