{
  "abstract": "Background\n\nEpidermal differentiation disorders (EDDs) are rare, chronic skin diseases with significant psychosocial impact on patients and families. Their daily management requires complex care, placing caregivers at risk of stress and anxiety. Few studies have systematically examined anxiety and coping strategies in this group.Objectives\n\nTo compare anxiety levels and coping styles between caregivers of children with syndromic or nonsyndromic EDD and caregivers of healthy children.Methods\n\nIn this cross-sectional case-control study, 39 caregivers of children with EDD and 39 matched controls were recruited from a dermatology clinic. Anxiety was assessed with the State-Trait Anxiety Inventory (STAI) and coping styles with the Coping Inventory for Stressful Situations (CISS). Sociodemographic and clinical data were collected.Results\n\nCaregivers of children with EDDs reported significantly higher trait anxiety than controls (79.5% vs. 53.8%; p = 0.017). Task-oriented coping (TOC) was less frequent among EDD caregivers, with more than half showing low TOC compared with less than one-third of controls (56.4% vs. 28.6%; p = 0.019). High avoidance-oriented coping (AOC) was observed more often in controls (21.4% vs. 5.6%; p = 0.044). Anxiety was greater among caregivers of boys than girls (95.7% vs. 56.2%; p = 0.003). Avoidant coping was associated with greater child symptom severity, including pruritus and redness.Conclusions\n\nCaregivers of children with EDD experience high anxiety and rely less on adaptive coping strategies. These findings emphasize the need for early, family-centered psychosocial interventions to support caregiver well-being and improve outcomes for affected children.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Palliative Medicine Collegium Medicum University of Zielona Góra Zielona Góra 65-046 Poland uz.zgora.pl.",
    "Department of Dermatology Venereology and Paediatric Dermatology Medical University of Lublin Lublin 20-080 Poland umlub.pl.",
    "Department of Laboratory Diagnostics Medical University of Lublin Lublin 20-059 Poland umlub.pl.",
    "Department of Medical Genetics Institute of Mother and Child Warsaw 01-211 Poland imid.med.pl.",
    "Department of Dermatology Maastricht UMC+ Center of Expertise for Genodermatoses University of Maastricht Maastricht University Medical Center+ Maastricht Netherlands maastrichtuniversity.nl.",
    "GROW School for Oncology and Reproduction Maastricht University Maastricht Netherlands maastrichtuniversity.nl."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Magdalena Fryze",
      "orcid": "0000-0002-7746-0086"
    },
    {
      "affs": [
        1
      ],
      "name": "Aldona Pietrzak",
      "orcid": "0000-0001-9494-6160"
    },
    {
      "affs": [
        2
      ],
      "name": "Radoslaw Mlak",
      "orcid": "0000-0001-7399-8340"
    },
    {
      "affs": [
        1
      ],
      "name": "Bartłomiej Wawrzycki",
      "orcid": "0000-0002-2172-701X"
    },
    {
      "affs": [
        3
      ],
      "name": "Katarzyna Wertheim-Tysarowska",
      "orcid": "0000-0001-9911-3811"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Fauve C A P van Veen",
      "orcid": "0000-0002-7786-4144"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Antoni H Gostynski",
      "orcid": "0000-0002-1091-2914"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5pa2c13cj244e.bib",
  "cited_by": 0,
  "doi": "10.1155/da/1126242",
  "fulltext_url": "https://europepmc.org/articles/PMC13711021",
  "id": "5pa2c13cj244e",
  "issns": [
    "1091-4269",
    "1520-6394"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948261",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "3203|Family and Disability Support Research"
    ]
  ],
  "openalex": "W7223790680",
  "pdf_url": "https://europepmc.org/articles/PMC13711021?pdf=render",
  "pmcid": "PMC13711021",
  "pmid": "42948261",
  "published": "2026-10-27",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/5pa2c13cj244e.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:33Z",
      "native_id": "MED:42948261",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948261"
    },
    {
      "first_seen": "2026-10-31T12:21:52Z",
      "native_id": "PMC13711021",
      "source": "pmc",
      "url": "https://doi.org/10.1155/da/1126242"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3203|Family and Disability Support Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Anxiety and Coping Strategies in Caregivers of Children With Epidermal Differentiation Disorders: A Case-Control Study.",
  "title_text": "Anxiety and Coping Strategies in Caregivers of Children With Epidermal Differentiation Disorders: A Case-Control Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:52Z",
  "url": "https://research.draconitic.com/paper/5pa2c13cj244e",
  "venue": "Depression and anxiety",
  "versions": []
}