{
  "abstract": "Background: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare biliary epithelial neoplasm with malignant potential. It is characterized by intraductal papillary growth, variable mucin production, and a close association with chronic biliary inflammation.\n\nCase presentation: We describe two patients with hepatolithiasis who developed IPNB after non-standardized biliary-enteric drainage without complete common bile duct transection. Both patients had long-term enterobiliary reflux and chronic cholangitis. Case 1 was diagnosed with intestinal-type IPNB with high-grade intraepithelial neoplasia and focal invasive mucinous adenocarcinoma and remained recurrence-free at 12 months despite a microscopically positive ductal margin (R1 resection). Case 2 had pancreatobiliary-type IPNB with moderately to poorly differentiated invasive adenocarcinoma and developed rapid postoperative peritoneal and distant metastases.\n\nConclusion: In these two patients with hepatolithiasis, non-standardized biliary-enteric drainage with a retained distal common bile duct and blind pouch was associated with long-term enterobiliary reflux, chronic cholangitis, and subsequent IPNB. These findings suggest a plausible contributing mechanism rather than an established causal relationship. When biliary-enteric reconstruction is otherwise indicated, surgical techniques that avoid a residual blind pouch and minimize enterobiliary reflux should be considered. Long-term surveillance may be warranted in patients with long-standing biliary inflammation after non-standardized drainage.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital/The First Affiliated Hospital of Hunan Normal University",
    "Department of Oncology, Hunan Provincial People’s Hospital/The First Affiliated Hospital of Hunan Normal University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinpeng Peng"
    },
    {
      "affs": [
        0
      ],
      "name": "Pingzhou Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Hao Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chuang Peng"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiguo Tan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5pe2nhvrm6dx1.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1980694",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1980694/full",
  "id": "5pe2nhvrm6dx1",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1980694/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "2746|Cholangiocarcinoma and Gallbladder Cancer Studies"
    ]
  ],
  "openalex": "W7223702844",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1980694/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5pe2nhvrm6dx1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1980694",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1980694/full"
    },
    {
      "first_seen": "2026-10-30T13:47:23Z",
      "native_id": "e46316c55292496dbddb8cc75a77826b",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fonc.2026.1980694"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cholangiocarcinoma and Gallbladder Cancer Studies",
      "subfield": "surgery"
    }
  ],
  "title": "Malignant transformation of intraductal papillary neoplasm of the bile duct following non-standardized biliary-enteric drainage for hepatolithiasis: two case reports and literature review",
  "title_text": "Malignant transformation of intraductal papillary neoplasm of the bile duct following non-standardized biliary-enteric drainage for hepatolithiasis: two case reports and literature review",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:23Z",
  "url": "https://research.draconitic.com/paper/5pe2nhvrm6dx1",
  "venue": "Frontiers in Oncology",
  "versions": []
}