{
  "abstract": "Long non-coding RNAs (lncRNAs) have diverse biological functions, but experimentally validated evidence remains scattered across the literature and is often context dependent. EVLncRNAs 4.0 (https://www.sdklab-biophysics-dzu.net/EVLncRNAs4/) updates our manually curated database of functional lncRNAs supported by low-throughput experiments. For this release, 16 581 publications indexed between 15 May 2023 and 15 May 2026 were retrieved and manually screened. Compared with EVLncRNAs 3.0, EVLncRNAs 4.0 contains 7808 functional lncRNAs (+26%) from 199 species (+23%), 2313 diseases (+34%), 28 757 curated functional records (+21%), and 18 380 molecular interactions (+25%). EVLncRNAs 4.0 also introduces two AI-assisted functions built on the curated evidence base. AI Search uses an enhanced retrieval-augmented generation framework with adaptive selection across Quick, Expanded, and Exhaustive retrieval modes and generates answers from retrieved EVLncRNAs records with PMID-linked citations. Benchmark evaluation showed complete request execution, high retrieval coverage and full citation validity within the supplied evidence context. Functional Overview retrieves and aggregates lncRNA- and species-specific curated records before generating concise evidence-based summaries. In both functions, language models synthesize retrieved evidence rather than serve as independent sources of biological knowledge. EVLncRNAs 4.0 therefore provides an expanded, experimentally grounded resource for accessing and interpreting functional lncRNA evidence across species and biological contexts.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Biophysics, Dezhou University , Dezhou 253023 ,",
    "College of Physics and Electronic Information, Dezhou University , Dezhou 253023 ,",
    "Gastrointestinal Surgery, Dezhou Second People’s Hospital , Dezhou 253000 ,",
    "Patent Examination Cooperation (Beijing) Center of the Patent Office, CNIPA , Beijing 100160 ,",
    "Belgorod Institute of Food Sciences, Dezhou University , Dezhou 253023 ,",
    "College of Computer and Information Engineering, Dezhou University , Dezhou 253023 ,",
    "College of Life Science, Dezhou University , Dezhou 253023 ,",
    "College of Mathematics and Big Data, Dezhou University , Dezhou 253023 ,",
    "Department of Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , Guangzhou 510120 ,",
    "School of Computer Science and Engineering, Sun Yat-Sen University , Guangzhou 510006 ,",
    "Institute of Systems and Physical Biology, Shenzhen Bay Laboratory , Shenzhen 518107 ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bailing Zhou",
      "orcid": "0000-0002-4824-347X"
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    {
      "affs": [
        1
      ],
      "name": "Baohua Ji"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhiwei Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhenghua Li"
    },
    {
      "affs": [
        3
      ],
      "name": "Chunjie Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xia Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Xue Yu"
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    {
      "affs": [
        0
      ],
      "name": "Pingping Huang"
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    {
      "affs": [
        0
      ],
      "name": "Li Kong"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Shuo Yang"
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    {
      "affs": [
        6
      ],
      "name": "Qiangcheng Zeng"
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    {
      "affs": [
        7
      ],
      "name": "Xianghua Dou"
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    {
      "affs": [
        0
      ],
      "name": "Zanxia Cao"
    },
    {
      "affs": [
        0
      ],
      "name": "Shicai Xu"
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    {
      "affs": [
        8
      ],
      "name": "Huiying Zhao",
      "orcid": "0000-0001-9134-536X"
    },
    {
      "affs": [
        0,
        9
      ],
      "name": "Yuedong Yang",
      "orcid": "0000-0002-6782-2813"
    },
    {
      "affs": [
        0,
        10
      ],
      "name": "Yaoqi Zhou",
      "orcid": "0000-0002-9958-5699"
    },
    {
      "affs": [
        0
      ],
      "name": "Jihua Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5ppwfxqx364g8.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag1111",
  "fulltext_url": null,
  "id": "5ppwfxqx364g8",
  "issns": [
    "0305-1048",
    "1362-4962"
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  "language": null,
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
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  "pdf_url": "https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkag1111/72639834/gkag1111.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/5ppwfxqx364g8.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:18Z",
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:0305-1048",
      "subfield": "molecular-biology"
    }
  ],
  "title": "EVLncRNAs 4.0: an updated database of experimentally validated functional long non-coding RNAs with evidence-grounded AI access",
  "title_text": "EVLncRNAs 4.0: an updated database of experimentally validated functional long non-coding RNAs with evidence-grounded AI access",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T00:21:29Z",
  "url": "https://research.draconitic.com/paper/5ppwfxqx364g8",
  "venue": "Nucleic Acids Research",
  "versions": []
}