{
  "abstract": "Hydroxyurea derivatives have important medicinal utility acting as enzyme inhibitors and anticancer agents. Their syntheses have, however, entailed low yielding routes employing long reaction times and toxic reagents such as phosgene. Towards sustainable and environmentally benign hydroxyurea synthesis, a one-step hydroxycarbamoylation approach is described employing resonant acoustic mixing (RAM) to expedite reactions at higher concentration. Eighteen medicinally relevant hydroxyurea were synthesized in 68-91% yields using ethanol as green solvent.",
  "abstract_shown": true,
  "affiliations": [
    "Département de Chimie, Complexe des Sciences, B-3015, 1375 Avenue Thérèse-Lavoie-Roux Montréal, Québec, Canada, H2V 0B3",
    "Studio Bioscience Inc., 111 Rue Terry Fox, Verdun, QC, H3E 1L4"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yousra Hamdane"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Felix Polyak"
    },
    {
      "affs": [
        0
      ],
      "name": "William D. Lubell"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5pskpsev41swt.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010860/v1",
  "fulltext_url": null,
  "id": "5pskpsev41swt",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010860/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Microwave-Assisted Synthesis and Applications"
    ]
  ],
  "openalex": "W7223176800",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010860/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/5pskpsev41swt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.26434/chemrxiv.15010860",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010860/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Microwave-Assisted Synthesis and Applications",
      "subfield": "organic"
    }
  ],
  "title": "Hydroxyurea synthesis using resonant acoustic mixing in ethanol",
  "title_text": "Hydroxyurea synthesis using resonant acoustic mixing in ethanol",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/5pskpsev41swt",
  "venue": "ChemRxiv",
  "versions": []
}