{
  "abstract": "Insomnia and depression frequently coexist, yet their shared biological mechanisms have not been systematically integrated, limiting the development of targeted preventive and therapeutic strategies. Growing evidence identifies immune dysregulation as a key link between insomnia and depression, with the microbiota-gut-brain axis providing an important mechanistic framework. This review summarizes how insomnia induced gut microbiota alterations disrupt intestinal homeostasis, promote peripheral and central inflammation, and impair synaptic function during depression. It also discusses dietary interventions, food derived bioactive compounds, probiotics, and other microbiota targeted strategies. Targeting microbiota mediated immune pathways may provide new opportunities for the prevention and treatment of insomnia related depression.",
  "abstract_shown": true,
  "affiliations": [
    "Chengdu University of Traditional Chinese Medicine",
    "Hospital of Chengdu University of Traditional Chinese Medicine"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Dan Tian"
    },
    {
      "affs": [
        0
      ],
      "name": "Hu Qi"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhizhong Luo"
    },
    {
      "affs": [
        1
      ],
      "name": "Jili Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Jie Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5q4zez05ntqgk.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1940701",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13728786/?tool=EBI",
  "id": "5q4zez05ntqgk",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1940701/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7223022532",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13728786/pdf/?tool=EBI",
  "pmcid": "PMC13728786",
  "pmid": "42979177",
  "published": "2026-10-20",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5q4zez05ntqgk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1940701",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1940701/full"
    },
    {
      "first_seen": "2026-11-04T15:20:45Z",
      "native_id": "PMC:PMC13728786",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13728786"
    },
    {
      "first_seen": "2026-11-07T12:21:42Z",
      "native_id": "PMC13728786",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fimmu.2026.1940701"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "From gut dysbiosis to synaptic dysfunction in insomnia-associated depression: immune mechanisms and nutritional interventions",
  "title_text": "From gut dysbiosis to synaptic dysfunction in insomnia-associated depression: immune mechanisms and nutritional interventions",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:42Z",
  "url": "https://research.draconitic.com/paper/5q4zez05ntqgk",
  "venue": "Frontiers in Immunology",
  "versions": []
}