{
  "abstract": "Cognitive fluctuations are a core feature of dementia with Lewy bodies (DLB). Research focuses largely on early stages. We investigated fluctuation frequency and correlates in advanced DLB. The Mayo Fluctuations Scale and Clinician Assessment of Fluctuations measured fluctuations. Analyses assessed frequency, scale correlations, and experiences correlating with baseline and longitudinal fluctuations. Fluctuations occurred in > 70% of the cohort across visits. Fluctuation scales correlated very weakly. Baseline fluctuations correlated with female sex, symptom burden, cognitive severity, neuropsychiatric symptom burden, hallucinations, sleepiness/alertness, parkinsonism, autonomic symptom burden, and orthostatic hypotension. Additional variables correlated with single scales. Fluctuations weakly correlated with participant quality of life and caregiver experiences. Longitudinal fluctuations correlated with other DLB features, comorbidities, and medication burden. Fluctuations are common in advanced DLB and correlate with other symptoms. Fluctuation measurement requires further conceptual and psychometric work for best approaches, including for screening and longitudinal assessments and treatment trials. NCT04829656.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology University of Florida College of Medicine Gainesville Florida USA.",
    "Norman Fixel Institute for Neurological Diseases Gainesville Florida USA.",
    "Department of Biostatistics University of Florida College of Medicine Gainesville Florida USA.",
    "Department of Psychiatry University of Michigan Ann Arbor Michigan USA.",
    "Department of Neurology & Rehabilitation Medicine University of Cincinnati Cincinnati Ohio USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Melissa J Armstrong"
    },
    {
      "affs": [
        2
      ],
      "name": "Tingchang Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tracy Tholanikunnel"
    },
    {
      "affs": [
        0
      ],
      "name": "Hannah Jury"
    },
    {
      "affs": [
        0
      ],
      "name": "Kaitlin Sovich"
    },
    {
      "affs": [
        3
      ],
      "name": "Susan M Maixner"
    },
    {
      "affs": [
        4
      ],
      "name": "Abhimanyu Mahajan"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhigang Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5q9jg6qvmhw8h.bib",
  "cited_by": 0,
  "doi": "10.1002/dad2.70519",
  "fulltext_url": "https://europepmc.org/articles/PMC13714082",
  "id": "5q9jg6qvmhw8h",
  "issns": [
    "2352-8729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953268",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7224102113",
  "pdf_url": "https://europepmc.org/articles/PMC13714082?pdf=render",
  "pmcid": "PMC13714082",
  "pmid": "42953268",
  "published": "2026-10-27",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/5q9jg6qvmhw8h.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:40Z",
      "native_id": "MED:42953268",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953268"
    },
    {
      "first_seen": "2026-11-01T12:21:38Z",
      "native_id": "PMC13714082",
      "source": "pmc",
      "url": "https://doi.org/10.1002/dad2.70519"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Fluctuations correlates in advanced dementia with Lewy bodies: A longitudinal study.",
  "title_text": "Fluctuations correlates in advanced dementia with Lewy bodies: A longitudinal study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:38Z",
  "url": "https://research.draconitic.com/paper/5q9jg6qvmhw8h",
  "venue": "Alzheimer's & dementia (Amsterdam, Netherlands)",
  "versions": []
}