{
  "abstract": "Rationale: Anxiety affects 22-56% of patients with chronic obstructive pulmonary disease and predicts exacerbations, readmissions, and mortality. Mind-body adjuncts to pulmonary rehabilitation are recommended, but trials have lacked comparators isolating technique-specific effects and left determinants of individual benefit unexamined. Objectives: Testing whether adjunctive medical hypnosis reduces anxiety more than matched structured relaxation. Methods: Cluster-randomized, active-comparator trial with patients undergoing pulmonary rehabilitation for chronic obstructive pulmonary disease. Consecutive 4-week inpatient cohorts were randomized 1:1 to adjunctive hypnosis or structured relaxation matched on session length, practitioner pool, and framing. Primary outcome was the six-item State-Trait Anxiety Inventory at week 4 (intention to treat). Complementary multidimensional metrics of anxiety were obtained for robustness. Exploratory analyses tested outcome moderation by baseline sensory-affective dyspnea burden. Measurements and Main Results: Of 80 participants (24 clusters), 79 were analyzed (hypnosis 36, relaxation 43). Hypnosis did not differ from relaxation on the primary outcome (+0.95 points; 95% credible interval -5.85 to 7.42; posterior probability of clinically important hypnosis advantage 0.12) or its complementary metrics. Anxiety improved in both arms (pooled -5.72 points; -9.35 to -2.00). Exploratory analyses showed that the hypnosis advantage rose with baseline sensory and fell with affective burden, reaching -9.26 points at a high-sensory, low-affective profile (-23.37 to 4.71; posterior probability of clinically important hypnosis advantage 0.81). No deaths or serious adverse events occurred. Conclusions: Anxiety improved with no advantage of hypnosis over matched relaxation. Exploratory analysis suggests greater hypnosis benefit in patients with predominantly sensory dyspnea, proposing a candidate phenotype for stratified trials.",
  "abstract_shown": true,
  "affiliations": [
    "INSERM, UMRS1158, University Hospital Pitie Salpetriere, Sorbonne University"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "A. Ghergan"
    },
    {
      "name": "B. Herer"
    },
    {
      "name": "F. Larue"
    },
    {
      "name": "D. Sambourg"
    },
    {
      "name": "I. Segundo"
    },
    {
      "name": "Y. Bocahu"
    },
    {
      "name": "C. Moulin"
    },
    {
      "name": "A. Delignieres"
    },
    {
      "name": "T. Similowski"
    },
    {
      "name": "C. Morelot-Panzini"
    },
    {
      "affs": [
        0
      ],
      "name": "H. Anllo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5qdz0gb9cvfrj.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.07.20.26358482",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.07.20.26358482v2.full",
  "id": "5qdz0gb9cvfrj",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.07.20.26358482v2",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "respiratory medicine"
    ],
    [
      "openalex",
      "2740|Chronic Obstructive Pulmonary Disease (COPD) Research"
    ]
  ],
  "openalex": "W7170090217",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.07.20.26358482v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5qdz0gb9cvfrj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:04Z",
      "native_id": "10.64898/2026.07.20.26358482",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.07.20.26358482v2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:respiratory medicine",
      "subfield": "general"
    }
  ],
  "title": "Hypnosis versus relaxation for anxiety in COPD pulmonary rehabilitation: a cluster-randomized trial",
  "title_text": "Hypnosis versus relaxation for anxiety in COPD pulmonary rehabilitation: a cluster-randomized trial",
  "type": "preprint",
  "updated_at": "2026-10-31T00:20:38Z",
  "url": "https://research.draconitic.com/paper/5qdz0gb9cvfrj",
  "venue": "medRxiv",
  "versions": []
}