{
  "abstract": "MeXpose 2.0 is a major update to our interactive workflow for comprehensive analysis of multiplexed imaging data, optimized for spatial metallomics. This release streamlined the existing pipeline by replacing third-party software with custom Jupyter notebooks for image reconstruction, preprocessing, and data extraction. Additional features such as limit-of-detection calculations, interactive region-of-interest annotations, cytometry-style gating, and integrated spatial statistics enhance both exploratory and quantitative analyses within a single, compact environment. MeXpose 2.0 is free and open-source, available at https://github.com/koellenspergerlab/mexpose under the MIT license. Additional test data are available at https://doi.org/10.5281/zenodo.20287869.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.",
    "Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, 1090 Vienna, Austria.",
    "Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria."
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Gabriel Braun",
      "orcid": "0009-0006-2796-3386"
    },
    {
      "affs": [
        0
      ],
      "name": "Lyndsey Hendriks",
      "orcid": "0009-0002-0189-5435"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Claude Molitor",
      "orcid": "0000-0002-5826-0847"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hoang Anh Nguyenová",
      "orcid": "0009-0005-7308-5417"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elisabeth Foels",
      "orcid": "0009-0007-7715-4373"
    },
    {
      "affs": [
        0
      ],
      "name": "Martin Schaier",
      "orcid": "0000-0003-4907-218X"
    },
    {
      "affs": [
        0
      ],
      "name": "Gunda Koellensperger",
      "orcid": "0000-0002-1460-4919"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5qmkcbjcfc3qm.bib",
  "cited_by": 0,
  "doi": "10.1021/cbmi.6c00070",
  "fulltext_url": "https://europepmc.org/articles/PMC13714941",
  "id": "5qmkcbjcfc3qm",
  "issns": [
    "2832-3637"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953662",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Technical Note"
    ],
    [
      "openalex",
      "1312|Single-cell and spatial transcriptomics"
    ]
  ],
  "openalex": "W7167934090",
  "pdf_url": "https://europepmc.org/articles/PMC13714941?pdf=render",
  "pmcid": "PMC13714941",
  "pmid": "42953662",
  "published": "2026-07-10",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/5qmkcbjcfc3qm.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953662",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953662"
    },
    {
      "first_seen": "2026-11-01T12:22:20Z",
      "native_id": "PMC13714941",
      "source": "pmc",
      "url": "https://doi.org/10.1021/cbmi.6c00070"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Single-cell and spatial transcriptomics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "MeXpose 2.0: A Comprehensive Toolkit for Single-Cell Spatial (Metall-)omicsCovering All Steps from Image Reconstruction to Integrative Analysis.",
  "title_text": "MeXpose 2.0: A Comprehensive Toolkit for Single-Cell Spatial (Metall-)omicsCovering All Steps from Image Reconstruction to Integrative Analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:20Z",
  "url": "https://research.draconitic.com/paper/5qmkcbjcfc3qm",
  "venue": "Chemical & biomedical imaging",
  "versions": []
}