{
  "abstract": "Bovine mastitis is a major infectious disease in dairy cattle, causing significant economic losses and compromising animal health and milk quality worldwide. Among its etiological agents, Staphylococcus aureus is a key contagious pathogen due to its ability to establish persistent intramammary infections and evade host immune responses and antimicrobial therapy. This review summarizes current knowledge on the epidemiology, pathogenesis, clinical presentation, diagnosis, and control of S. aureus in bovine mastitis. Particular emphasis is placed on virulence mechanisms, including adhesion, intracellular persistence, biofilm formation, and immune evasion, which contribute to chronic and recurrent infections. The increasing prevalence of antimicrobial resistance, including methicillin-resistant and multidrug-resistant strains, is highlighted as a major challenge limiting treatment efficacy and posing risks within a One Health context. The review also discusses emerging alternative therapies and innovative control strategies, such as anti-biofilm approaches, immunomodulation, and improved diagnostics, aimed at reducing antimicrobial use. Advances in molecular and point-of-care diagnostic tools are considered for their role in early detection and targeted interventions. Overall, effective control of S. aureus mastitis requires integrated strategies combining prudent antimicrobial use, alternative therapies, improved hygiene, and a multidisciplinary One Health approach.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Microbiology, Immunology and Epidemiology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cosmina Maria BOUARI"
    },
    {
      "affs": [
        0
      ],
      "name": "G. Nadăş",
      "orcid": "0000-0003-2363-4041"
    },
    {
      "affs": [
        0
      ],
      "name": "Smaranda Crăciun",
      "orcid": "0000-0002-1330-6581"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicodim Iosif FIT",
      "orcid": "0000-0003-1062-1890"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5qncgvna11fhw.bib",
  "cited_by": 5,
  "doi": "10.3390/microorganisms14051125",
  "fulltext_url": null,
  "id": "5qncgvna11fhw",
  "issns": [
    "2076-2607"
  ],
  "landing_url": "https://doi.org/10.3390/microorganisms14051125",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1102|Milk Quality and Mastitis in Dairy Cows"
    ],
    [
      "openalex",
      "1103|Milk Quality and Mastitis in Dairy Cows"
    ]
  ],
  "openalex": "W7161280570",
  "pdf_url": null,
  "pmcid": "PMC13210330",
  "pmid": "42197509",
  "published": "2026-05-15",
  "publisher": "Multidisciplinary Digital Publishing Institute",
  "ris": "https://research.draconitic.com/paper/5qncgvna11fhw.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:09Z",
      "native_id": "W7161280570",
      "source": "openalex",
      "url": "https://doi.org/10.3390/microorganisms14051125"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1102|Milk Quality and Mastitis in Dairy Cows",
      "subfield": "plant-biology"
    },
    {
      "field": "biology",
      "origin": "openalex:1103|Milk Quality and Mastitis in Dairy Cows",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Staphylococcus aureus in Bovine Mastitis: Pathogenesis, Antimicrobial Resistance, and Emerging Control Strategies",
  "title_text": "Staphylococcus aureus in Bovine Mastitis: Pathogenesis, Antimicrobial Resistance, and Emerging Control Strategies",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:09Z",
  "url": "https://research.draconitic.com/paper/5qncgvna11fhw",
  "venue": "Microorganisms",
  "versions": []
}