{
  "abstract": "OBJECTIVE: Circadian and sleep disruption may increase the risk and severity of SARS-CoV-2 infections, but the role of night shift work and disturbed sleep in the development of long-COVID remains inadequately investigated. We prospectively examined the association of night work and sleep disturbances with risk of long-COVID. METHODS: We followed participants of the COVICAT study, a population-based cohort of adults in Catalonia, Spain between 2021 and 2023. Night shift work and sleep characteristics were assessed in 2021. Long-COVID was defined as the report of persistent symptoms (>3 months) after a SARS-CoV-2 infection. Poisson regression analysis was performed to evaluate the independent and joint effects of night shift work and sleep disturbances including chronic insomnia with risk of long-COVID. Analyses were stratified by sex, body mass index and chronotype. RESULTS: During the two-year follow-up, 284 of the 1899 newly infected participants reported long-COVID symptoms. Compared to day workers, night shift workers had 88% higher risk of developing long-COVID [95% confidence interval (CI) 1.29–2.72], after adjusting for potential confounders. The risk further increased among night workers with obesity. Chronic insomnia in the general population was associated with 42% increased risk of long-COVID (95% CI 1.12–1.78). Night workers with chronic insomnia had a 2.7 fold higher long-COVID risk (95% CI 1.60–4.51) compared to day workers without chronic insomnia. Associations persisted in various sensitivity analyses. CONCLUSIONS: Our findings from a large prospective cohort indicate that night shift work and poor sleep are independently and jointly associated with a higher risk of long-COVID.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "Kyriaki Papantoniou"
    },
    {
      "name": "Ana Espinosa"
    },
    {
      "name": "Marianna Karachaliou"
    },
    {
      "name": "Camille Lassale"
    },
    {
      "name": "Gemma Castaño-Vinyals"
    },
    {
      "name": "Barbara N Harding"
    },
    {
      "name": "Sara De Matteis"
    },
    {
      "name": "Kurt Straif"
    },
    {
      "name": "Eva Alonso-Nogués"
    },
    {
      "name": "Carlota Dobaño"
    },
    {
      "name": "Gemma Moncunill"
    },
    {
      "name": "Natalia Blay"
    },
    {
      "name": "Susana Iraola-Guzmán"
    },
    {
      "name": "Rafael de Cid"
    },
    {
      "name": "Judith Garcia-Aymerich"
    },
    {
      "name": "Manolis Kogevinas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5qy8a4dzchfbd.bib",
  "cited_by": 0,
  "doi": "10.5271/sjweh.4318",
  "fulltext_url": "https://www.sjweh.fi/Night-work-sleep-disruption-and-long-COVID-risk-a-population-based-cohort-study,241516,0,2.html",
  "id": "5qy8a4dzchfbd",
  "issns": [
    "0355-3140",
    "1795-990X"
  ],
  "landing_url": "https://doi.org/10.5271/sjweh.4318",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RA1-1270"
    ],
    [
      "openalex",
      "2728|Long-Term Effects of COVID-19"
    ]
  ],
  "openalex": "W7172450291",
  "pdf_url": "https://www.sjweh.fi/download.php?abstract_id=4318&file_nro=1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-01",
  "publisher": "Nordic Association of Occupational Safety and Health (NOROSH)",
  "ris": "https://research.draconitic.com/paper/5qy8a4dzchfbd.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:22:35Z",
      "native_id": "0c8a28f7c8e2457fbbfbb2b766ca3259",
      "source": "doaj",
      "url": "https://doi.org/10.5271/sjweh.4318"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Long-Term Effects of COVID-19",
      "subfield": "neurology"
    }
  ],
  "title": "Night work, sleep disruption and long-COVID risk: a population-based cohort study",
  "title_text": "Night work, sleep disruption and long-COVID risk: a population-based cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:35Z",
  "url": "https://research.draconitic.com/paper/5qy8a4dzchfbd",
  "venue": "Scandinavian Journal of Work, Environment & Health",
  "versions": []
}