{
  "abstract": "Calcified neurocysticercosis (NCC), traditionally considered an inert marker of past infection, is increasingly recognized as a clinically meaningful condition associated with migraine-like headaches. Evidence from population-based cohorts, clinical series, and imaging studies consistently shows that individuals with calcified NCC have a higher prevalence and severity of headache than those without lesions. Prospective neuroimaging demonstrates that intermittent perilesional inflammation, including edema and blood-brain barrier disruption, can activate migraine-generating pathways, with calcitonin gene-related peptide-mediated trigeminovascular sensitization emerging as a key mechanism. These findings challenge the assumption that calcified lesions are clinically irrelevant and instead, support the concept of a distinct inflammation-driven headache phenotype. Recognizing this entity has important implications for diagnosis, counseling, and therapeutic decision-making, particularly in endemic regions where calcifications are common and often dismissed as incidental. Calcified NCC also provides a unique human model for understanding how focal neuroinflammation shapes headache susceptibility.",
  "abstract_shown": true,
  "affiliations": [
    "Research Center, Universidad Espíritu Santo-Ecuador, Samborondón, Ecuador."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Oscar H Del Brutto"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5r38q31a3ewby.bib",
  "cited_by": 0,
  "doi": "10.4269/ajtmh.26-0374",
  "fulltext_url": "https://europepmc.org/articles/PMC13694910",
  "id": "5r38q31a3ewby",
  "issns": [
    "0002-9637",
    "1476-1645"
  ],
  "landing_url": "https://europepmc.org/article/MED/42901156",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Parasitic infections in humans and animals"
    ]
  ],
  "openalex": "W7222999407",
  "pdf_url": "https://europepmc.org/articles/PMC13694910?pdf=render",
  "pmcid": "PMC13694910",
  "pmid": "42901156",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5r38q31a3ewby.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42901156",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42901156"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Parasitic infections in humans and animals",
      "subfield": "general"
    }
  ],
  "title": "Headache in Calcified Neurocysticercosis: Emerging Insights into an Inflammation-Driven Phenotype.",
  "title_text": "Headache in Calcified Neurocysticercosis: Emerging Insights into an Inflammation-Driven Phenotype.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/5r38q31a3ewby",
  "venue": "The American journal of tropical medicine and hygiene",
  "versions": []
}