{
  "abstract": "Plasma extracellular vesicles (EVs) are promising liquid biopsy biomarkers, yet their proteomic profiling remains confounded by massive co-isolation. Here, we resolve this heterogeneity through a meta-analysis of 515 human plasma EV proteomes. We demonstrate that the reproducible core proteome is overwhelmingly governed by predictable, surface-charge-driven mass-action that dynamically mirrors synthetic nanoparticle corona formation. By quantitatively decomposing the core isolate against pan-synthetic coronas and agonist-induced platelet EVs, we trace the core isolate to three main mechanistic origins: an electrostatic plasma corona, ex vivo platelet vesiculation and biological macromolecular co-isolates. Crucially, the residual vesicular cargo strongly correlates with thrombin-induced platelet degranulation, indicating that phlebotomy-induced trauma contribute to the bulk signal. We provide a modular atlas that mathematically distinguishes biophysical coronas from these cellular co-isolates, establishing a new framework for interpreting biological origin in plasma EV proteomics.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Ana Sofia Carvalho",
      "orcid": "0000-0003-0657-1907"
    },
    {
      "name": "Juan M. Falcón-Pérez",
      "orcid": "0000-0003-3133-0670"
    },
    {
      "name": "Hans Christian Beck",
      "orcid": "0000-0002-7763-3637"
    },
    {
      "name": "Rune Matthiesen",
      "orcid": "0000-0002-6353-2616"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5r59ajnh9d8sa.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11038-6",
  "fulltext_url": "https://europepmc.org/articles/PMC13722686",
  "id": "5r59ajnh9d8sa",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11038-6",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.nature.com/articles/s42003-026-11038-6.pdf",
  "pmcid": "PMC13722686",
  "pmid": "42963372",
  "published": "2026-10-30",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/5r59ajnh9d8sa.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:18Z",
      "native_id": "10.1038/s42003-026-11038-6",
      "source": "feed-nature",
      "url": "https://www.nature.com/articles/s42003-026-11038-6"
    },
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "10.1038/s42003-026-11038-6",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11038-6"
    },
    {
      "first_seen": "2026-11-02T03:21:21Z",
      "native_id": "MED:42963372",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42963372"
    },
    {
      "first_seen": "2026-11-04T12:21:27Z",
      "native_id": "PMC13722686",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s42003-026-11038-6"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "Analysis of 515 human proteomes defines plasma extracellular vesicle core composition, corona and coisolated networks",
  "title_text": "Analysis of 515 human proteomes defines plasma extracellular vesicle core composition, corona and coisolated networks",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:27Z",
  "url": "https://research.draconitic.com/paper/5r59ajnh9d8sa",
  "venue": "Communications Biology",
  "versions": []
}