{
  "abstract": "The prognostic value of the systemic immune-inflammation index (SII) in critically ill patients with acute asthma exacerbations remains unclear. This study examined the association between SII and in-hospital mortality. We performed a retrospective cohort study using the MIMIC-IV (v3.1) database, including adult critically ill patients with asthma exacerbations. SII was calculated from laboratory values obtained during the peri-intensive care unit admission period. The primary outcome was in-hospital mortality. Associations were assessed using restricted cubic spline and Cox proportional hazards models, adjusted for confounders. A total of 575 patients were included, with an overall in-hospital mortality of 6.6%. Mortality rates differed significantly across SII tertiles and were highest in tertile 3 (11.5%), compared with tertile 2 (3.6%) and tertile 1 (4.7%) (P = .003). In Cox proportional hazards models, compared with tertile 2, patients in tertile 3 had a significantly increased risk of in-hospital mortality (unadjusted hazard ratio [HR] 2.88, 95% confidence interval [CI] 1.21-6.83, P = .016; adjusted HR 2.82, 95% CI 1.12-7.10, P = .027), whereas no significant difference was observed for tertile 1. Restricted cubic spline analysis based on natural logarithm-transformed (ln-SII) demonstrated a significant nonlinear association with in-hospital mortality (P for nonlinearity < .001), with risk increasing markedly at higher ln-SII levels. Elevated SII was associated with increased in-hospital mortality and may serve as a simple prognostic marker in critically ill asthma exacerbations.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medicine, College of Health Sciences, Nam Can Tho University, Can Tho, Vietnam.",
    "Critical Care Department, Nam Can Tho University Medical Center, Can Tho, Vietnam."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Phan Ngoc An Huynh",
      "orcid": "0009-0003-6400-8992"
    },
    {
      "affs": [
        0
      ],
      "name": "Vu Thanh Le",
      "orcid": "0009-0002-8292-0515"
    },
    {
      "affs": [
        0
      ],
      "name": "Ngoc Thu Le"
    },
    {
      "affs": [
        0
      ],
      "name": "Ngoc Nhu Y Nguyen",
      "orcid": "0009-0005-0287-1947"
    },
    {
      "affs": [
        0
      ],
      "name": "Van Hoang Nam Ho",
      "orcid": "0009-0003-6019-6009"
    },
    {
      "affs": [
        0
      ],
      "name": "Thi Thu Phuong Lam"
    },
    {
      "affs": [
        0
      ],
      "name": "Khoi Minh Tran"
    },
    {
      "affs": [
        0
      ],
      "name": "Cong Dang Tran"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Thanh Luan Nguyen",
      "orcid": "0009-0001-0117-9482"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5r6ktcwgej8bv.bib",
  "cited_by": 0,
  "doi": "10.1097/md.0000000000051080",
  "fulltext_url": "https://europepmc.org/articles/PMC13680952",
  "id": "5r6ktcwgej8bv",
  "issns": [
    "0304-5412",
    "1536-5964"
  ],
  "landing_url": "https://europepmc.org/article/MED/42888589",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7222417582",
  "pdf_url": "https://europepmc.org/articles/PMC13680952?pdf=render",
  "pmcid": "PMC13680952",
  "pmid": "42888589",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/5r6ktcwgej8bv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42888589",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42888589"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "Systemic immune-inflammation index and in-hospital mortality in critically ill patients with acute asthma exacerbation: A retrospective cohort study.",
  "title_text": "Systemic immune-inflammation index and in-hospital mortality in critically ill patients with acute asthma exacerbation: A retrospective cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/5r6ktcwgej8bv",
  "venue": "Medicine",
  "versions": []
}