{
  "abstract": "Background: Viscoelastic testing is commonly used to assess fibrinolytic phenotypes in trauma, with values of thromboelastogram (TEG) clot lysis at 30 minutes after maximum amplitude (LY30) >3% considered indicative of hyperfibrinolysis. The \"Fibrinolytic Activation Screening Test\" (FAST) is a rapid assay that detects endogenous tissue plasminogen activator–dependent and plasmin-dependent fibrinolytic activation.\n\nObjectives: This study aimed to evaluate FAST activity in trauma and determine its correlation with other indices of fibrinolytic activation, including plasmin-antiplasmin (PAP) complexes and TEG LY30.\n\nMethods: FAST activity and PAP complexes were assayed in archived plasma samples from 99 patients with trauma on presentation. We evaluated the association of FAST activity with 4 different PAP thresholds (>2000 ng/mL, >5000 ng/mL, >10,000 ng/mL, or >20,000 ng/mL) representing increasing degrees of fibrinolytic activation.\n\nResults: FAST activity was elevated in 65% of patients with trauma on admission. By Spearman’s rank correlation, FAST activity was strongly correlated with PAP complexes (rs = 0.74). The strong association of FAST activity with all 4 PAP thresholds was more pronounced with increasing cutoffs, indicating enhanced specificity of FAST activity with greater fibrinolytic activation. TEG LY30 showed no correlation with FAST activity (rs = –0.07) and no correlation with PAP complexes (rs = –0.18). In an exploratory analysis, the FAST assay demonstrated good discriminatory performance for in-hospital mortality by receiver operating characteristic analysis (area under the curve, 0.8023; 95% CI, 0.6417-0.9630).\n\nConclusion: The FAST assay is a rapid and specific measure of fibrinolytic activation in trauma.",
  "abstract_shown": true,
  "affiliations": [
    "Blood Research Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA",
    "Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA",
    "Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA",
    "Department of Surgery, University of Colorado-Denver/Anschutz Medical Campus, Denver, Colorado, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anton Ilich"
    },
    {
      "affs": [
        0
      ],
      "name": "Izabela Pawlinski"
    },
    {
      "affs": [
        1
      ],
      "name": "Matthew J. Eckert"
    },
    {
      "affs": [
        1
      ],
      "name": "Linda E. Sousse"
    },
    {
      "affs": [
        1
      ],
      "name": "Jared R. Gallaher"
    },
    {
      "affs": [
        2
      ],
      "name": "Myung S. Park"
    },
    {
      "affs": [
        3
      ],
      "name": "Alyssa Caldwell-McGee"
    },
    {
      "affs": [
        3
      ],
      "name": "Mitchell J. Cohen"
    },
    {
      "affs": [
        3
      ],
      "name": "Jessica C. Cardenas"
    },
    {
      "affs": [
        0
      ],
      "name": "Nigel S. Key"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5ryka4dcereex.bib",
  "cited_by": 0,
  "doi": "10.1016/j.rpth.2026.106999",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734932/",
  "id": "5ryka4dcereex",
  "issns": [
    "2475-0379"
  ],
  "landing_url": "https://doi.org/10.1016/j.rpth.2026.106999",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2706|Trauma, Hemostasis, Coagulopathy, Resuscitation"
    ]
  ],
  "openalex": "W7215127951",
  "pdf_url": "https://www.rpthjournal.org/article/S2475-0379(26)03657-5/pdf",
  "pmcid": "PMC13734932",
  "pmid": "42990657",
  "published": "2026-10-01",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/5ryka4dcereex.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:43Z",
      "native_id": "PMC13734932",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.rpth.2026.106999"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2706|Trauma, Hemostasis, Coagulopathy, Resuscitation",
      "subfield": "general"
    }
  ],
  "title": "Rapid plasma-based screening of fibrinolytic activation in trauma: a single-center observational cohort study",
  "title_text": "Rapid plasma-based screening of fibrinolytic activation in trauma: a single-center observational cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:43Z",
  "url": "https://research.draconitic.com/paper/5ryka4dcereex",
  "venue": "Research and Practice in Thrombosis and Haemostasis",
  "versions": []
}