{
  "abstract": "Objective: To investigate whether endoscopic ultrasound (EUS)-guided targeted epinephrine injection is associated with a lower rate of bleeding during endoscopic mucosal resection (EMR).\n\nMethods: This retrospective cohort study enrolled consecutive patients undergoing EMR for gastrointestinal lesions ≥1 cm with an EUS-detectable feeding vessel at Zhengzhou Central Hospital between January 2025 and March 2026. Patients were non-randomly assigned to EUS-guided targeted epinephrine injection (1:20,000) or EUS assessment followed by conventional submucosal saline injection. The primary outcome was immediate intraoperative bleeding; secondary outcomes included delayed bleeding, procedure time, hospital stay, en bloc resection rate, and adverse events. Multivariable logistic regression was performed, with Firth regression and propensity-score (PSM and IPTW) sensitivity analyses to address confounding.\n\nResults: Among 84 patients (injection group, n = 31; control group, n = 53), immediate intraoperative bleeding occurred in 0% versus 24.5% (P = 0.002). Two delayed bleeding cases (3.8%) occurred in the control group only. No between-group differences were observed in procedure time, hospital stay, or adverse events; the en bloc resection rate was 100% in both groups. EUS-guided targeted epinephrine injection was associated with reduced odds of intraoperative bleeding (OR = 0.112, 95% CI 0.028–0.443, P = 0.002), consistent across Firth regression, PSM, and IPTW analyses.\n\nConclusion: EUS-guided targeted epinephrine injection was associated with lower immediate intraoperative bleeding during EMR without prolonging procedure time or hospital stay. These hypothesis-generating findings require confirmation in prospective randomized studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wanting Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Aimei Rong"
    },
    {
      "affs": [
        0
      ],
      "name": "Chan Liao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongli Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiaqi Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Qianping Liang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5s040k79rt87m.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1985945",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724387/?tool=EBI",
  "id": "5s040k79rt87m",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13724387",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2715|Gastrointestinal Bleeding Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7222923618",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724387/pdf/?tool=EBI",
  "pmcid": "PMC13724387",
  "pmid": "42973476",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/5s040k79rt87m.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13724387",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13724387"
    },
    {
      "first_seen": "2026-11-04T12:22:58Z",
      "native_id": "PMC13724387",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1985945"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42973476",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973476"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Gastrointestinal Bleeding Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "EUS-guided targeted epinephrine injection and immediate intraoperative bleeding during endoscopic mucosal resection: a retrospective cohort study (with video)",
  "title_text": "EUS-guided targeted epinephrine injection and immediate intraoperative bleeding during endoscopic mucosal resection: a retrospective cohort study (with video)",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:21:09Z",
  "url": "https://research.draconitic.com/paper/5s040k79rt87m",
  "venue": "Frontiers in medicine",
  "versions": []
}