{
  "abstract": "Anti-IgLON5 disease is an autoimmune disease, in which autoantibodies (AABs) against the neuronal cell surface protein IgLON5 lead to profound brain dysfunction and Tau pathology. How α-IgLON5 AABs cause neuronal Tau protein pathology and neurodegeneration remains unclear. We find that patient-derived α-IgLON5 AABs cluster IgLON5 proteins with other cell surface proteins, leading to neuronal hyperactivity that triggers pathological Tau missorting and phosphorylation, typically observed early in Tau-related neurodegenerative diseases. In wild-type mice, α-IgLON5 AABs induce hippocampal Tau phosphorylation and neuroinflammatory responses. Our findings establish a causal link between the α-IgLON5 AABs and Tau pathology in anti-IgLON5 disease patients and highlight the role of neuronal hyperactivity as a disease-overarching driver of Tau pathology and provide a potential target for therapeutic intervention.",
  "abstract_shown": true,
  "affiliations": [
    "Einstein Center for Neurosciences (ECN), Charité – Universitätsmedizin Berlin; Berlin, Germany",
    "German Center for Neurodegenerative Diseases (DZNE); Berlin, Germany",
    "Department of Neurology and Experimental Neurology, Charité – Universitätsmedizin Berlin; Berlin, Germany",
    "Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin; Berlin, Germany",
    "Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University; Magdeburg, Germany",
    "German Center for Neurodegenerative Diseases (DZNE); Munich, Germany",
    "Munich Cluster for Systems Neurology (SyNergy); Munich, Germany",
    "Neuroproteomics, School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich; Munich, Germany",
    "Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn; Bonn, Germany",
    "German Center for Neurodegenerative Diseases (DZNE); Bonn, Germany",
    "Platform for Single Cell Genomics and Epigenomics (PRECISE) at the German Center for Neurodegenerative Diseases and the University of Bonn; Bonn, Germany",
    "Metabolic Biochemistry, Biomedical Center Munich (BMC), Faculty of Medicine, Ludwig Maximilian University; Munich, Germany",
    "Institute of Integrative Neuroanatomy, Charité; Berlin, Germany",
    "Institute of Cell Biology and Neurobiology, Charité – Universitätsmedizin Berlin; Berlin, Germany",
    "German Center for Neurodegenerative Diseases (DZNE); Magdeburg, Germany",
    "Neuroscience Research Center (NWFZ), Charité-Universitätsmedizin; Berlin, Germany"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 31,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Bilge Askin",
      "orcid": "0000-0002-6582-3249"
    },
    {
      "affs": [
        1
      ],
      "name": "Cagla Kilic"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "César Cordero Gómez"
    },
    {
      "affs": [
        3,
        2,
        1
      ],
      "name": "Sophie Lan-Linh Duong",
      "orcid": "0000-0002-9216-0874"
    },
    {
      "affs": [
        1
      ],
      "name": "Alvaro Dominguez‐Baquero"
    },
    {
      "affs": [
        4
      ],
      "name": "Alexander Goihl",
      "orcid": "0000-0002-8652-5136"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Karsten Nalbach",
      "orcid": "0000-0002-3928-4026"
    },
    {
      "affs": [
        1
      ],
      "name": "Joana Petushi",
      "orcid": "0009-0003-5359-2126"
    },
    {
      "affs": [
        8,
        9,
        10
      ],
      "name": "Pia Grundschöttel"
    },
    {
      "affs": [
        5,
        11,
        6
      ],
      "name": "Jessica Wagner",
      "orcid": "0009-0004-8585-6998"
    },
    {
      "affs": [
        1
      ],
      "name": "Valentine Thomas",
      "orcid": "0009-0004-3791-1796"
    },
    {
      "affs": [
        1
      ],
      "name": "Janne Lamberty"
    },
    {
      "affs": [
        1
      ],
      "name": "Emily Withers",
      "orcid": "0009-0003-1619-8541"
    },
    {
      "affs": [
        9
      ],
      "name": "Hanna Huber",
      "orcid": "0009-0004-3080-6870"
    },
    {
      "affs": [
        1
      ],
      "name": "Sabrina Hübschmann"
    },
    {
      "affs": [
        1
      ],
      "name": "Ekaterina Semenova"
    },
    {
      "affs": [
        12
      ],
      "name": "Paul Turko",
      "orcid": "0000-0002-1305-6711"
    },
    {
      "affs": [
        13
      ],
      "name": "Andrew G. Newman",
      "orcid": "0000-0002-0222-9162"
    },
    {
      "affs": [
        1
      ],
      "name": "Lisa Diez",
      "orcid": "0000-0003-3101-0191"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Marc Beyer",
      "orcid": "0000-0001-9704-148X"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Elena De Domenico",
      "orcid": "0000-0003-0336-8284"
    },
    {
      "affs": [
        2,
        14
      ],
      "name": "Péter Körtvelyessy",
      "orcid": "0000-0003-1262-6169"
    },
    {
      "affs": [
        4
      ],
      "name": "Dirk Reinhold",
      "orcid": "0000-0002-6441-9631"
    },
    {
      "affs": [
        9
      ],
      "name": "Anja Schneider",
      "orcid": "0000-0001-9540-8700"
    },
    {
      "affs": [
        5,
        11,
        6
      ],
      "name": "Jonas J. Neher",
      "orcid": "0000-0003-1346-8924"
    },
    {
      "affs": [
        8,
        9,
        10
      ],
      "name": "T Ulas"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Stefan F. Lichtenthaler",
      "orcid": "0000-0003-2211-2575"
    },
    {
      "affs": [
        1
      ],
      "name": "Benjamin R. Rost",
      "orcid": "0000-0003-1906-0081"
    },
    {
      "affs": [
        0,
        1,
        13,
        15
      ],
      "name": "Dietmar Schmitz",
      "orcid": "0000-0003-2741-5241"
    },
    {
      "affs": [
        2,
        0,
        1
      ],
      "name": "Harald Prüß",
      "orcid": "0000-0002-8283-7976"
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    {
      "affs": [
        0,
        1
      ],
      "name": "Susanne Wegmann",
      "orcid": "0000-0002-5388-2479"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5s2zgwc4dhkvr.bib",
  "cited_by": 9,
  "doi": "10.1126/sciadv.aec2042",
  "fulltext_url": null,
  "id": "5s2zgwc4dhkvr",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://doi.org/10.1126/sciadv.aec2042",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
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      "2728|Autoimmune Neurological Disorders and Treatments"
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  "pdf_url": null,
  "pmcid": "PMC13170660",
  "pmid": "42127169",
  "published": "2026-05-13",
  "publisher": "American Association for the Advancement of Science",
  "ris": "https://research.draconitic.com/paper/5s2zgwc4dhkvr.ris",
  "sources": [
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      "first_seen": "2026-10-30T13:26:56Z",
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      "url": "https://doi.org/10.1126/sciadv.aec2042"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Autoimmune Neurological Disorders and Treatments",
      "subfield": "neurology"
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  ],
  "title": "IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity",
  "title_text": "IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T13:20:37Z",
  "url": "https://research.draconitic.com/paper/5s2zgwc4dhkvr",
  "venue": "Science Advances",
  "versions": []
}