{
  "abstract": "Background: Chronic kidney disease (CKD) is a major condition with a substantial sociomedical and economic burden. Klotho plays a role in renal protection via its antioxidant and anti-inflammatory properties. Proteinuria is an early indicator of CKD. Although experimental studies have demonstrated the biological effects of Klotho in CKD, its clinical relevance to proteinuria remains unclear.\n\nMethods: The present study investigated the association between the A/T alleles of the Klotho gene rs650439 single-nucleotide polymorphism (SNP) and proteinuria in a general Japanese population. Clinical and genotyping data from a total of 916 community-dwelling participants (mean age = 63 years old) were analyzed.\n\nResults: Participants carrying the minor TT genotype accounted for 13.2% of the population. The prevalence of proteinuria was significantly higher in the TT group than in the AA + AT group (15.7% vs. 7.3%, P < 0.01). Logistic regression analysis showed that the TT genotype was significantly associated with proteinuria (crude odds ratio (OR) = 2.37, 95% confidence interval (CI) 1.35–4.14). This association remained significant after adjustment for age, sex, and cardiometabolic factors (adjusted OR = 2.07, 95% CI 1.14–3.77).\n\nConclusions: These findings suggest that the TT genotype of Klotho gene rs650439 SNP may serve as a genetic marker for early renal proteinuria. Further research is required to confirm the findings.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Community Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan",
    "Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan",
    "Division of Mineral Metabolism, Center for Molecular Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Masato Hamasaki"
    },
    {
      "affs": [
        0
      ],
      "name": "Kazuhiko Kotani"
    },
    {
      "affs": [
        1
      ],
      "name": "Yoshitaka Iwazu"
    },
    {
      "affs": [
        2
      ],
      "name": "Makoto Kuro-o"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/5s50zvq8k4av6.bib",
  "cited_by": 0,
  "doi": "10.14740/jocmr6669",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719641/?tool=EBI",
  "id": "5s50zvq8k4av6",
  "issns": [
    "1918-3003",
    "1918-3011"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13719641",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2727|Parathyroid Disorders and Treatments"
    ]
  ],
  "openalex": "W7223408970",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719641/pdf/?tool=EBI",
  "pmcid": "PMC13719641",
  "pmid": "42964217",
  "published": "2026-10-01",
  "publisher": "Elmer Press",
  "ris": "https://research.draconitic.com/paper/5s50zvq8k4av6.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13719641",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13719641"
    },
    {
      "first_seen": "2026-11-02T12:23:34Z",
      "native_id": "PMC13719641",
      "source": "pmc",
      "url": "https://doi.org/10.14740/jocmr6669"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Parathyroid Disorders and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Klotho Gene Single-Nucleotide Polymorphism and Proteinuria in a General Population",
  "title_text": "Klotho Gene Single-Nucleotide Polymorphism and Proteinuria in a General Population",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:40Z",
  "url": "https://research.draconitic.com/paper/5s50zvq8k4av6",
  "venue": "Journal of Clinical Medicine Research",
  "versions": []
}